European Journal of Clinical Microbiology & Infectious Diseases ( IF 3.7 ) Pub Date : 2021-04-16 , DOI: 10.1007/s10096-021-04241-2 Dolors Rodríguez-Pardo 1, 2, 3 , María Dolores Del Toro 2, 3, 4 , Laura Guío-Carrión 2, 3, 5 , Rosa Escudero-Sánchez 3, 6 , Marta Fernández-Sampedro 2, 3, 7 , Miguel Ángel García-Viejo 3, 8 , María Velasco-Arribas 3, 9 , Laura Soldevila-Boixader 3, 10 , Magdalena Femenias 11 , José Antonio Iribarren 3, 12 , María Del Carmen Pulido-Garcia 13 , María Dolores Navarro 2, 3, 4 , Mayli Lung 2, 3, 14 , Pablo S Corona 2, 3, 15 , Benito Almirante 1, 2, 3 , Carles Pigrau 1, 2, 3
Purpose
To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture.
Methods
Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB. Primary outcome: early-PJI after HHA.
Results
Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin-trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33–3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15–7.10]).
Conclusions
Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47
中文翻译:
无症状菌尿在髋关节置换术后早期假体周围关节感染中的作用。BARIFER 随机临床试验
目的
评估术前无症状菌尿 (ASB) 治疗以减少髋关节半髋置换术 (HHA) 骨折后早期假体周围关节感染 (early-PJI)。
方法
开放标签、多中心 RCT 比较磷霉素-氨丁三醇与无干预与无 ASB 的平行随访队列。主要结果:HHA 后的早期 PJI。
结果
招募了 594 名患者(平均年龄 84.3 岁);152 (25%) 名使用 ASB(77 名使用磷霉素-氨丁三醇治疗/75 名对照)和 442 名(75%)未使用。尽管研究在没有预期样本量的情况下结束,但 ASB 不能预测早期 PJI(OR:1.06 [95%CI:0.33-3.38]),并且其治疗没有改变早期 PJI 的发生率(OR:1.03 [95% CI:0.15–7.10])。
结论
术前 ASB 及其治疗似乎都不是 HHA 后早期 PJI 的危险因素。ClinicalTrials.gov 标识符:Eudra CT 2016-001108-47