This study tests the predictions of a novel analysis of recognition memory based on a theory of associative learning, according to which recognition comprises two independent underlying processes, one relying on the to-be-recognized item having been experienced recently (self-generated priming), and the other on it being predicted by some other stimulus (retrieval-generated priming). A single experiment examined recognition performance in the amyloid precursor protein (APP)swe/PS1dE9 (APP/PS1) mouse, a double-transgenic model of Alzheimer's disease (AD), and wild type (WT) littermates. Performance on two variants of the spontaneous object recognition (SOR) was compared in 5-month-old APPswe/PS1dE9 (APP/PS1) mice, a double-transgenic model of AD, and their WT littermates, using junk objects. In the relative recency task animals were exposed to object A, and then object B, followed by a test with both A and B. In the object-in-place task the mice were exposed to both A and B, and then tested with two copies of A, occupying the same positions as the preeexposed objects. The WT mice showed a preference for exploring the first-presented object A in the relative recency task, and the copy of A in the "wrong" position (i.e., the one placed where B had been during the preexposure phase) in the object-in-place task. The APP/PS1 mice performed like the WT mice in the relative recency task, but showed a selective impairment in the object-in-place task. We interpret these findings in terms of-Wagner's (Information processing in animals: Memory Mechanisms, 1981, Erlbaum) theory of associative learning, sometimes opponent process (SOP), as a selective deficit in retrieval-generated priming. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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时间还是地点？年轻 APPswe/PS1dE9 小鼠中对象就地和相对新近之间的分离。

本研究测试了基于联想学习理论的识别记忆新分析的预测，根据该理论，识别包括两个独立的潜在过程，一个依赖于最近经历过的待识别项目（自生成启动） ，另一个是由其他一些刺激（检索生成的启动）预测的。一项单一实验检查了淀粉样前体蛋白 (APP)swe/PS1dE9 (APP/PS1) 小鼠、阿尔茨海默病 (AD) 的双转基因模型和野生型 (WT) 同窝仔鼠的识别性能。使用垃圾对象在 5 个月大的 APPswe/PS1dE9 (APP/PS1) 小鼠、AD 双转基因模型及其 WT 同窝小鼠中比较了两种自发物体识别 (SOR) 变体的性能。在相对新近任务中，动物先接触物体 A，然后接触物体 B，然后用 A 和 B 进行测试。在就地任务中，小鼠同时接触 A 和 B，然后用两种A 的副本，占据与预曝光对象相同的位置。WT 小鼠在相对新近任务中表现出对探索第一个呈现的对象 A 的偏好，以及对象中“错误”位置（即，B 在暴露前阶段放置的位置）中的 A 副本 -就地任务。APP/PS1 小鼠在相对新近任务中的表现与 WT 小鼠相似，但在对象就地任务中表现出选择性损伤。我们根据-Wagner（动物信息处理：记忆机制，1981，Erlbaum）的联想学习理论来解释这些发现，有时对手过程（SOP），作为检索生成启动的选择性缺陷。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。