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Neutron Scattering Techniques and Complementary Methods for Structural and Functional Studies of Biological Macromolecules and Large Macromolecular Complexes
Crystallography Reports ( IF 0.7 ) Pub Date : 2021-04-16 , DOI: 10.1134/s1063774521020103
D. V. Lebedev , V. V. Egorov , A. V. Shvetsov , Y. A. Zabrodskaya , V. V. Isaev-Ivanov , A. L. Konevega

Abstract

The review describes the application of small-angle scattering (SAS) of neutrons and complementary methods to study the structures of biomacromolecules. Here we cover SAS techniques, such as the contrast variation, the neutron spin-echo, and the solution of direct and inverse problems of three-dimensional reconstruction of the structures of macromolecules from SAS spectra by means of molecular modeling. A special section is devoted to specific objects of research, such as supramolecular complexes, influenza virus nucleoprotein, and chromatin.



中文翻译:

用于生物大分子和大分子复合物结构和功能研究的中子散射技术和补充方法

摘要

这篇综述描述了中子的小角度散射(SAS)的应用和互补方法,以研究生物大分子的结构。在这里,我们介绍了SAS技术,例如对比度变化,中子自旋回波以及通过分子建模从SAS光谱对高分子结构进行三维重建的正反问题的解决方案。一个特殊的部分专门研究特定的研究对象,例如超分子复合物,流感病毒核蛋白和染色质。

更新日期:2021-04-16
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