Background

Glycated hemoglobin has been a popular investigation to access the glycemic status. It is a marker for intracellular glycation, and hence, an investigation which can comply with both intracellular and extracellular glycation statuses is preferred.

Methodology

In this regard, fructosaminated HbA1c (FHbA_1c), predicted HbA1c (PHbA_1c) and glycation gap (GG) were evaluated in 57 cases of diabetes mellitus (DM) without complication and having a normal serum protein and albumin levels. Fifty controls were also evaluated. FHbA_1c, PHbA_1c and post-prandial predicted HbA1c (PPHbA_1c) were plotted using population linear regression equation and calculated individually against each subject. The statistical calculation was evaluated using SPSS version 21.

Results

FHbA_1c, PHbA_1c, PPHbA_1c and GG were found to be significantly elevated in cases (p value < 0.001). FHbA_1c and GG show significant correlation with the glycemic indices in cases compared to controls. The correlation with FBS and PPBS increases as we move from controls to cases. Area under curve (AUC) in case of FHbA_1c is 96.8%, and cut-off level of 5.85% can result in sensitivity of 88.2% and specificity of 90% for the diagnosis of DM.

Conclusion

FHbA_1c can be used as an additional investigation in cases of DM. Along with GG, it is increased in DM and correlates with the glycemic indices. It has a decent AUC on plotting ROC. Thus, FHbA_1c and GG can be used as a part of glyco-metabolic profile and can provide insight into the individualised glycation tendency of the cell.

中文翻译：

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预测的HbA1c和果糖化的HbA1c：评估其作为糖尿病血糖状况指标的作用：一项基于医院的横断面研究

背景

糖化血红蛋白是获得血糖状态的流行研究。它是细胞内糖基化的标志物，因此，优选能够同时满足细胞内和细胞外糖基化状态的研究。

方法

在这方面，对57例无并发症且血清蛋白和白蛋白水平正常的糖尿病（DM）患者评估了果糖化HbA1c（FHbA _1c），预测HbA1c（PHbA _1c）和糖化缺口（GG）。还评估了五十个对照。使用总体线性回归方程绘制FHbA _1c，PHbA _1c和餐后预测的HbA1c（PPHbA _1c）并针对每个受试者分别进行计算。使用SPSS 21版评估统计计算。

结果

发现FHbA _1c，PHbA _1c，PPHbA _1c和GG在病例中显着升高（p值<0.001）。与对照组相比，FHbA _1c和GG与血糖指数显着相关。随着我们从对照转移到病例，与FBS和PPBS的相关性增加。对于FHbA _1c，曲线下面积（AUC）为96.8％，并且截止水平为5.85％可导致诊断DM的敏感性为88.2％，特异性为90％。

结论

FHbA _1c可以作为DM的补充检查。它与GG一起在DM中增加，并与血糖指数相关。它在绘制ROC方面有不错的AUC。因此，FHbA _1c和GG可以用作糖代谢曲线的一部分，并可以洞悉细胞的个体糖基化趋势。