Breaching the phagosome, the case of the tuberculosis agent,Cellular Microbiology

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Breaching the phagosome, the case of the tuberculosis agent
Cellular Microbiology ( IF 2.6 ) Pub Date : 2021-04-15 , DOI: 10.1111/cmi.13344
Roxane Simeone ₁ , Fadel Sayes ₁ , Emeline Lawarée ₁ , Roland Brosch ₁

Affiliation

The interactions between microbes and their hosts are among the most complex biological phenomena known today. The interaction may reach from overall beneficial interaction, as observed for most microbiome/microbiota related interactions to interaction with virulent pathogens, against which host cells have evolved sophisticated defence strategies. Among the latter, the confinement of invading pathogens in a phagosome plays a key role, which often results in the destruction of the invader, whereas some pathogens may counteract phagosomal arrest and survive by gaining access to the cytosol of the host cell. In the current review, we will discuss recent insights into this dynamic process of host-pathogen interaction, using Mycobacterium tuberculosis and related pathogenic mycobacteria as main examples.

中文翻译：

突破吞噬体，结核菌案例

微生物与其宿主之间的相互作用是当今已知的最复杂的生物现象之一。这种相互作用可以从整体有益的相互作用（如大多数微生物组/微生物群相关的相互作用所观察到的）到与有毒病原体的相互作用，宿主细胞已经进化出复杂的防御策略。在后者中，入侵病原体在吞噬体中的限制起着关键作用，这通常会导致入侵者的破坏，而一些病原体可能会通过进入宿主细胞的细胞质来抵消吞噬体的阻滞并存活下来。在当前的综述中，我们将讨论对宿主-病原体相互作用的这种动态过程的最新见解，以结核分枝杆菌和相关的致病性分枝杆菌为主要例子。

更新日期：2021-06-23

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