Materials used for biosensor development normally include silicon, glass, and synthetic polymers, however, paper is a practical and cheap option for the reduction of manufacturing costs with a wide range of applications. Paper-based biosensors have been widely produced, yet poorly characterized on the interaction of different type of molecules with its intricate microstructure. In this work, five ink solutions were prepared as model samples to examine their diffusion and imbibition behavior on grade 3MM chromatography paper. Different mathematical models, previously reported for porous matrices, were fitted and results revealed that upward wicking (r² ≥ 0.90) equations described the experimental data during the initial stage (< 5 s) and yielded similar permeability values to those calculated from the matrix structural properties. The diffusion coefficient was determined up to attaining equilibrium using the diffusion equation in a cylinder element (r² ≥ 0.90). This study enabled the characterization of the performance from 3MM chromatography paper, by using ink as a surrogate model of small molecules (e.g. mycotoxins) or small colloidal particles.

用于生物传感器开发的材料通常包括硅，玻璃和合成聚合物，但是，纸是一种在广泛的应用中降低制造成本的实用且廉价的选择。纸基生物传感器已经被广泛生产，但是在不同类型的分子与其复杂的微结构之间的相互作用方面却具有较差的特征。在这项工作中，准备了五种墨水溶液作为模型样品，以检查它们在3MM级色谱纸上的扩散和吸收行为。拟合了先前报道的用于多孔基质的不同数学模型，结果表明向上芯吸（r ² ≥0.90）方程描述了初始阶段（<5 s）的实验数据，并得出了与根据基体结构特性计算得出的渗透率值相似的渗透率值。测定扩散系数高达使用在气缸元件的扩散方程式达到平衡（R ²  ≥0.90）。这项研究通过使用墨水作为小分子（例如霉菌毒素）或小胶体颗粒的替代模型，来表征3MM色谱纸的性能。