Friedel-Crafts acylation reaction is a well-known reaction to synthesize acetophenone derivatives, which have a broad spectrum of bioactivity. However, Friedel-Crafts acylation mostly used acetyl chloride as a reagent with Lewis acid as a homogeneous catalyst, which is a nonenvironmental friendly process. In this work, a simple and efficient Friedel-Crafts acylation reaction is reported using the activated bentonite impregnated with PdO (PdOAB) as the heterogeneous catalyst. The PdOAB catalyst material was prepared through a two-steps reaction, i.e., an acid activation of natural bentonite and impregnation of palladium(II) nitrate under alkaline conditions. The optimum condition of the acetophenone synthesis was evaluated using the catalyst material by varying the catalyst mass and reaction time. The acetophenone derivatives with R = -H, -Cl, -CH₃, -OCH₃, -OH, and -NH₂ at the para position were successfully synthesized from its corresponding aromatic compounds with glacial acetic acid in 86.6, 7.9, 91.7, 86.6, 82.7, and 78.9% yield, respectively. From the experimental results, we proposed that the catalysis mechanism was mainly facilitated by the acid sites of the PdOAB catalyst material. The PdOAB catalyst material did not significantly lose its catalytic activity after four-cycle processes. Therefore, a green method for acetophenone synthesis was established because the byproduct is water, and the catalyst material can be recovered.

Friedel-Crafts酰化反应是合成具有广泛生物活性的苯乙酮衍生物的众所周知的反应。但是，Friedel-Crafts酰化反应主要使用乙酰氯作为试剂，路易斯酸为均相催化剂，这是一种非环境友好的工艺。在这项工作中，据报道，使用浸渍有PdO（PdOAB）的活性膨润土作为非均相催化剂，可以进行简单有效的Friedel-Crafts酰化反应。PdOAB催化剂材料是通过两步反应制备的，即，是在碱性条件下对天然膨润土的酸活化作用和硝酸钯（II）的浸渍作用。通过改变催化剂的质量和反应时间，使用催化剂材料评价了苯乙酮合成的最佳条件。R = -H，-Cl，-CH ₃，-OCH ₃，-OH和-NH ₂的苯乙酮衍生物在对位上成功地由其相应的芳族化合物与冰醋酸合成了收率分别为86.6％，7.9％，91.7％，86.6％，82.7％和78.9％的冰醋酸。从实验结果，我们认为，PdOAB催化剂材料的酸位主要促进了催化机理。在四循环过程之后，PdOAB催化剂材料没有明显丧失其催化活性。因此，因为副产物是水，所以可以建立绿色的苯乙酮合成方法，并且可以回收催化剂材料。