The eukaryotic translation elongation factors (EEFs), i.e. EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step of translation but are often altered in cancer. Less investigated are their pseudogenes. Recently, it was demonstrated that pseudogenes have a key regulatory role in the cell, especially via non-coding RNAs, and that the aberrant expression of ncRNAs has an important role in cancer development and progression. The present review paper, for the first time, collects all that published about the EEFs pseudogenes to create a base for future investigations. For most of them, the studies are in their infancy, while for others the studies suggest their involvement in normal cell physiology but also in various human diseases. However, more investigations are needed to understand their functions in both normal and cancer cells and to define which can be useful biomarkers or therapeutic targets.

真核翻译延伸因子(EEF)，即EEF1A1、EEF1A2、EEF1B2、EEF1D、EEF1G、EEF1E1和EEF2 ，是在翻译延伸步骤中发挥核心作用但在癌症中经常改变的编码基因。对它们的假基因的研究较少。最近，研究证明假基因在细胞中具有关键的调节作用，特别是通过非编码RNA，并且ncRNA的异常表达在癌症的发生和进展中具有重要作用。本综述论文首次收集了所有已发表的有关 EEF 假基因的文章，为未来的研究奠定了基础。对于其中大多数人来说，这些研究还处于起步阶段，而对于其他人来说，研究表明它们不仅参与正常细胞生理学，而且还参与各种人类疾病。然而，需要更多的研究来了解它们在正常细胞和癌细胞中的功能，并确定哪些可以作为有用的生物标志物或治疗靶点。