Background: Coenzyme Q10 (CoQ10) has been known as ubiquinone or ubidecarenone, which is a kind of lipid-soluble and vitamin-like antioxidant. It has a potent antioxidant effect against oxidation status via various mechanisms, including its ability to regenerate other antioxidants, such as vitamin E and vitamin C, and to increase antioxidant enzymes. Moreover, CoQ10 can quench free radicals and prevent lipid peroxidation. The aim of this systematic review and meta-analysis was to evaluate the effect of CoQ10 on oxidative stress variables. Methods: A comprehensive electronic database search in Scopus, Web of Science, Embase, Cochrane Library, and Medline was performed to identify eligible randomized clinical trials. A meta-analysis of included studies was performed on selected variables using a random-effects model. Quality assessment was conducted by means of the Cochrane risk of bias assessment tool. Results: To evaluate the effect of CoQ10 supplementation, 17 trials and 972 participants were included for the meta-analysis. The pooled analysis of primary studies showed that CoQ10 increased serum total antioxidant capacity (standardized mean difference [SMD] 0.62 mmol/L, 95% CI 0.18–1.05, I² = 76.1%, p ˂ 0.001) and superoxide dismutase (SMD 0.40 U/mg, 95% CI 0.12–0.67, I² = 9.6%, p ˂ 0.345) levels and decreased malondialdehyde (SMD –1.02 mmol/L, 95% CI –1.60 to –0.44, I² = 88.2%, p ˂ 0.001) level significantly compared to the placebo group. Although the effect of CoQ10 on nitric oxide (SMD 1.01 µmol/L, 95% CI –1.53 to 3.54, p ˂ 0.001, I² = 97.8%) and glutathione peroxidase (SMD –0.01 mmol/L, 95% CI –0.86 to 0.84, p ˂ 0.001, I² = 88.6%) was not significant, CoQ10 can be mentioned as an improvement in antioxidant defense status against reactive oxygen species. Conclusion: These supplements have positive effects on antioxidant defense against oxidizing agents and elevate antioxidant enzyme levels in the body. However, due to limited research the results should be taken with caution.
Complement Med Res

中文翻译：

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糖尿病、年龄和补充亚组分析辅酶 Q10 对氧化应激影响的持续时间：系统评价和荟萃分析

背景：辅酶Q10（CoQ10）被称为泛醌或泛醌，是一种脂溶性维生素类抗氧化剂。它通过各种机制对氧化状态具有强大的抗氧化作用，包括再生其他抗氧化剂（如维生素 E 和维生素 C）的能力，以及增加抗氧化酶的能力。此外，辅酶Q10可以淬灭自由基，防止脂质过氧化。本系统回顾和荟萃分析的目的是评估 CoQ10 对氧化应激变量的影响。方法：在 Scopus、Web of Science、Embase、Cochrane 图书馆和 Medline 中进行了全面的电子数据库搜索，以确定符合条件的随机临床试验。使用随机效应模型对所选变量进行纳入研究的荟萃分析。通过 Cochrane 偏倚风险评估工具进行质量评估。结果：为了评估补充 CoQ10 的效果，17 项试验和 972 名参与者被纳入荟萃分析。初步研究的汇总分析表明，辅酶 Q10 增加血清总抗氧化能力（标准化平均差 [S​​MD] 0.62 mmol/L，95% CI 0.18–1.05，I ² = 76.1%，p˂ 0.001）和超氧化物歧化酶（SMD 0.40 U /mg, 95% CI 0.12–0.67, I² = 9.6%, p ˂ 0.345) 水平和丙二醛 (SMD –1.02 mmol/L, 95% CI –1.60 至 –0.44, I ² = 88.2%, p ˂ 0.001) 水平与安慰剂组相比显着降低。虽然 CoQ10 对一氧化氮 (SMD 1.01 µmol/L, 95% CI –1.53 to 3.54, p ˂ 0.001, I ² = 97.8%) 和谷胱甘肽过氧化物酶 (SMD –0.01 mmol/L, 95% CI –0.86 to 0.84, p ˂ 0.001, I ² = 88.6%) 不显着，CoQ10 可以说是对活性氧的抗氧化防御状态的改善。结论：这些补充剂对抗氧化剂的抗氧化防御和提高体内抗氧化酶水平具有积极作用。但是，由于研究有限，因此应谨慎对待结果。
补充医学资源