On March 2020, hydroxychloroquine (HCQ) was recommended as a treatment for COVID-19 high risk patients. Following the massive and widespread use of HCQ worldwide, a discernible high quantity is anticipated to end-up through the sewage systems in marine coastal areas. A closed microcosm study was undertaken herein for 30 days where meiobenthic nematodes were exposed to a range of HCQ concentrations (3.162, 31.62 and 63.24 μg.ml⁻¹). After one month of exposure in HCQ, the total abundances and Shannon-Wiener index of the assemblages decreased, whereas the individual mass and the Trophic Diversity Index increased at the highest concentrations. Overall, a numerical negative impact was observed for the epistrate feeders and non-selective deposit feeders, however, this benefited to the omnivores-carnivores, and particularly to the Oncholaimids. Such responses of the nematodes 2B and the corresponding taxa are bioindicative of current- or post-COVID-19 crisis risks in relation with the bioaccumulation of HCQ in seafood.

2020 年 3 月，羟氯喹 (HCQ) 被推荐作为 COVID-19 高危患者的治疗药物。随着 HCQ 在全球范围内的大规模和广泛使用，预计会有大量 HCQ 最终通过海洋沿海地区的污水系统排放。此处进行了为期 30 天的封闭微观世界研究，其中小型底栖线虫暴露于一系列 HCQ 浓度（3.162、31.62 和 63.24 μg.ml ^-1). 暴露于 HCQ 一个月后，组合的总丰度和 Shannon-Wiener 指数下降，而个体质量和营养多样性指数在最高浓度下增加。总体而言，观察到上位饲养者和非选择性沉积饲养者的数值负面影响，然而，这有利于杂食性食肉动物，尤其是 Oncholaimids。线虫 2B 和相应分类群的这种反应是当前或后 COVID-19 危机风险的生物指示，与海鲜中 HCQ 的生物积累有关。