ABSTRACT

Objective

Investigate the associations between self-reported physical activity (PA) engagement and white matter (WM) health (i.e. volume, integrity, and hyperintensities) in older Latinos.

Design

Cross-sectional study with community-dwelling older adults from predominantly Latino neighborhoods. Participants: Thirty-four cognitively healthy older Latinos from two different cohorts. Measurements: Participants self-reported demographic information, PA engagement [Community Healthy Activities Model Program for Seniors (CHAMPS) Physical Activity Questionnaire for Older Adults] and magnetic resonance imaging (MRI). We used high-resolution three-dimensional T1- and T2-FLAIR weighted images and diffusion tensor imaging acquired via 3 T MRI. We performed a series of hierarchical linear regression models with the addition of relevant covariates to examine the associations between self-reported PA levels and WM volume, integrity, and hyperintensities (separately). We adjusted p-values with the use of the Benjamini-Hochberg's false discovery rate procedure.

Results

Higher reported levels of leisure-time moderate-to-vigorous PA were significantly associated with higher WM volume of the posterior cingulate (β = 0.220, SE = 0.125, 95% CI 0.009-0.431, p = 0.047) and isthmus cingulate (β = 0.212, SE = 0.110, 95% CI 0.001-0.443, p = 0.044) after controlling for intracranial volume. Higher levels of total PA were significantly associated with higher overall WM volume of these same regions (posterior cingulate: β = 0.220, SE = 0.125, CI 0.024-0.421, p = 0.046; isthmus cingulate: β = 0.220, SE = 0.125, 95% CI 0.003-0.393; p = 0.040). Significant p-values did not withstand Benjamini-Hochberg’s adjustment. PA was not significantly associated with WM integrity or WM hyperintensities.

Conclusion

Higher levels of PA, particularly higher leisure-time moderate-to-vigorous PA, might be associated with greater WM volume in select white matter regions key to brain network integration for physical and cognitive functioning in older Latinos. More research is needed to further confirm these associations.

中文翻译：

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拉丁裔老年人体力活动水平与脑白质的关联

摘要

客观的

研究老年拉丁美洲人自我报告的身体活动 (PA) 参与度与白质 (WM) 健康（即体积、完整性和高强度）之间的关联。

设计

对来自主要拉丁裔社区的社区老年人进行横断面研究。参与者：来自两个不同群体的 34 名认知健康的老年拉丁裔美国人。测量：参与者自我报告的人口统计信息、PA 参与度 [老年人社区健康活动模型计划 (CHAMPS) 老年人身体活动问卷] 和磁共振成像 (MRI)。我们使用通过 3 T MRI 获取的高分辨率三维 T1 和 T2-FLAIR 加权图像以及扩散张量成像。我们执行了一系列分层线性回归模型，并添加了相关协变量，以检查自我报告的 PA 水平与 WM 体积、完整性和高信号之间的关联（分别）。我们使用 Benjamini-Hochberg 的错误发现率程序调整p值。

结果

较高的休闲时间中度至剧烈 PA 水平与较高的后扣带回 WM 体积显着相关 (β = 0.220, SE = 0.125, 95% CI 0.009-0.431, p = 0.047) 和扣带峡部 ( β  = 0.212，SE = 0.110，95% CI 0.001-0.443，p  = 0.044）控制颅内容量后。较高水平的总 PA 与这些相同区域较高的总体 WM 体积显着相关（后扣带回：β = 0.220，SE = 0.125，CI 0.024-0.421，p = 0.046；扣带峡部：β = 0.220，SE =  0.125，95 % CI 0.003-0.393；p  = 0.040）。显着的p值无法承受 Benjamini-Hochberg 的调整。PA 与 WM 完整性或 WM 高信号没有显着相关性。

结论

较高水平的 PA，尤其是较高的闲暇时间中度至剧烈 PA，可能与特定白质区域的 WM 体积增加有关，这些白质区域对于老年人的身体和认知功能的大脑网络整合至关重要。需要更多的研究来进一步证实这些关联。