Abstract

Purpose

This study sought to ascertain whether there might be an association between radon concentrations and age, gender, histologic type, and tumor stage at diagnosis.

Materials and methods

Lung cancer cases from different multicenter case-control studies were analyzed, and clinical data were retrieved from electronic health records and personal interviews. A radon device was placed in all dwellings of participants, and we then tested the existence of an association between residential radon and lung cancer characteristics at diagnosis.

Results

Of the total of 829 lung cancer cases included, 56.7% were smokers or ex-smokers. There was no association between indoor radon concentrations and age, gender, histologic type or tumor stage at diagnosis. Median indoor radon concentrations increased with age at diagnosis for men, but not for women. When analyzing participants exposed to more than 1000 Bq/m³, a predominance of small cell lung cancer and a higher presence of advanced stages (IIIB and IV) were observed.

Conclusions

There seems to be no association between radon and age, gender, histologic type or tumor stage at diagnosis. Higher radon exposure is more frequent in the case of small-cell lung cancer.

中文翻译：

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住宅氡气与肺癌诊断时的特征

 抽象的

 目的

本研究试图确定氡气浓度与诊断时的年龄、性别、组织学类型和肿瘤分期之间是否存在关联。

 材料和方法

对来自不同多中心病例对照研究的肺癌病例进行了分析，并从电子健康记录和个人访谈中检索了临床数据。在参与者的所有住宅中放置了氡气装置，然后我们在诊断时测试了住宅氡气与肺癌特征之间是否存在关联。

 结果

在总共 829 例肺癌病例中，56.7% 是吸烟者或戒烟者。室内氡气浓度与诊断时的年龄、性别、组织学类型或肿瘤分期之间没有关联。男性室内氡浓度中值随着诊断时年龄的增加而增加，但女性则不然。在分析暴露于超过 1000 Bq/m ³的参与者时，观察到小细胞肺癌占主导地位并且晚期阶段（IIIB 和 IV）的比例更高。

 结论

氡气与诊断时的年龄、性别、组织学类型或肿瘤分期似乎没有关联。小细胞肺癌的氡暴露量越高。