ABSTRACT

Carbapenem-resistant Acinetobacter baumannii strains are increasing worldwide. In this study, samples were collected from hospital environments, extra hospital environments, and fecal carriages. 76% (89/117) of bacterial isolates were detected as A. baumannii strains. The imipenem resistance in the hospital environment, fecal carriages, extra hospital environments, and clinical isolates was 37.7% (17/45), 100% (9/9), 0% (0/45), and 92.9% (92/99), respectively. The blaVIM and blaOXA-23 were detected in 6.6% (3/45) and 2.2% (1/45) of strains isolated from hospital environments. Interestingly, strains isolated from fecal carriages had blaVIM, blaOXA-23, and blaIMP genes which resembled carbapenem resistance genes in clinical strains. The structure of clonal relatedness among all non-clinical isolates was as follows: CC2, 37% (33/89); CC1, 22.4% (20/89); CC3, 12.3% (11/89); CC25, 7.8% (7/89); CC10, 4.4% (4/89) and CC15, 2.2% (2/89). Comparison of clonal relatedness among clinical and non-clinical isolates indicated that widespread clones including CC2, CC3, and CC10 were common clonal complexes between two categories.

摘要

耐碳青霉烯类鲍曼不动杆菌菌株在全球范围内不断增加。在这项研究中，样本是从医院环境、医院外环境和粪便车中收集的。76% (89/117) 的细菌分离株被检测为鲍曼不动杆菌菌株。医院环境、粪便运输、医院外环境和临床分离株的亚胺培南耐药率分别为 37.7% (17/45)、100% (9/9)、0% (0/45) 和 92.9% (92/99) ）， 分别。在从医院环境中分离出的 6.6% (3/45) 和 2.2% (1/45) 的菌株中检测到bla VIM 和bla OXA-23。有趣的是，从粪便车厢中分离出的菌株具有bla VIM、bla OXA-23 和blaIMP 基因与临床菌株中的碳青霉烯类抗性基因相似。所有非临床分离株的克隆相关性结构如下：CC2，37%（33/89）；CC1, 22.4% (20/89); CC3, 12.3% (11/89); CC25, 7.8% (7/89); CC10, 4.4% (4/89) 和 CC15, 2.2% (2/89)。临床和非临床分离株之间的克隆相关性比较表明，包括CC2、CC3和CC10在内的广泛克隆是两类之间常见的克隆复合物。