The spices, cinnamon and turmeric have both culinary and pharmaceutical applications. Earlier studies proved their effect on reducing the symptoms associated with type 2 diabetes, a major lifestyle disease affecting millions world over. In our work, we prepared a bi-herbal extract of cinnamon and turmeric and studied its effect to alleviate the symptoms of type 2 diabetes in rat model. The phenolic rich bi-herbal extract was given to diabetes induced male wistar rats for 28 days at two different concentrations (50 and 150 mg/Kg bwt.). The changes in blood glucose level were monitored at weekly interval. At the end of the experiment, blood serum was collected and used for the estimation of lipid profile, Glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Total Protein (TP), Albumin, Urea and Creatinine levels. The serum analysis revealed that administration of the bi-herbal extract at 150 mg/Kg bwt. significantly reduced the blood glucose level (152.60 ± 40.2 mg/dL; p < 0.05) of diabetic animals as compared to diabetic control (335.40 ± 67.3 mg/dL; p < 0.05) at the end of 4 weeks. The treatment also resulted in the reduction of total cholesterol and LDL-cholestrol levels as compared to diabetic control animals. The histopathological examination of tissues showed the improvement in pancreatic architecture and restoration of tissue integrity in liver and kidney. The study concludes that methanol extract of combination of cinnamon and turmeric has good hypoglycemic, hypolipidemic and organ protective potential in diabetic rats which could be developed into functional food supplementation for the prevention of type 2 diabetes.

中文翻译：

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肉桂和姜黄的双草药提取物的植物治疗潜力：体内抗糖尿病研究

香料，肉桂和姜黄既有烹饪用途，也有制药用途。较早的研究证明，它们可以减轻2型糖尿病的症状，而2型糖尿病是一种影响全世界数百万人的主要生活方式疾病。在我们的工作中，我们制备了肉桂和姜黄的双草药提取物，并研究了其减轻大鼠模型2型糖尿病症状的作用。将富含酚的双草药提取物以两种不同的浓度（50和150 mg / Kg bwt。）给予糖尿病诱导的雄性wistar大鼠28天。每周监测血糖水平的变化。实验结束时，收集血清并用于评估血脂，葡萄糖，天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），碱性磷酸酶（ALP），总蛋白（TP），白蛋白，尿素和肌酐水平。血清分析表明，以150 mg / Kg bwt的量施用双草药提取物。在4周结束时，与糖尿病对照组（335.40±67.3 mg / dL; p <0.05）相比，糖尿病动物的血糖水平显着降低（152.60±40.2 mg / dL; p <0.05）。与糖尿病对照动物相比，该治疗还导致总胆固醇和LDL-胆固醇水平降低。组织的组织病理学检查显示胰腺结构得到改善，肝脏和肾脏组织恢复完整。研究得出的结论是，肉桂和姜黄的甲醇提取物具有良好的降血糖作用，