Parkinson's disease and diabetes mellitus are two chronic disorders associated with aging that are becoming increasingly prevalent worldwide. Parkinson is a multifactorial progressive condition with no available disease modifying treatments at the moment. Over the last few years there is growing interest in the relationship between diabetes (and impaired insulin signaling) and neurodegenerative diseases, as well as the possible benefit of antidiabetic treatments as neuroprotectors, even in non-diabetic patients. Insulin regulates essential functions in the brain such as neuronal survival, autophagy of toxic proteins, synaptic plasticity, neurogenesis, oxidative stress and neuroinflammation. We review the existing epidemiological, experimental and clinical evidence that supports the interplay between insulin and neurodegeneration in Parkinson's disease, as well as the role of antidiabetic treatments in this disease.

帕金森氏病和糖尿病是两种与衰老相关的慢性疾病，它们在世界范围内变得越来越普遍。帕金森是一种多因素进行性疾病，目前没有可用的疾病改善疗法。在过去的几年中，人们对糖尿病（和受损的胰岛素信号传导）与神经退行性疾病之间的关系以及抗糖尿病治疗作为神经保护剂的可能益处的兴趣日益浓厚，即使在非糖尿病患者中也是如此。胰岛素调节大脑中的基本功能，例如神经元存活、有毒蛋白质的自噬、突触可塑性、神经发生、氧化应激和神经炎症。我们回顾了现有的流行病学，