Background. Accurate diagnosis of benign and malignant lymphadenopathy is important for determining the appropriate treatment and prognosis. This study evaluated the diagnostic accuracy and usefulness of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a conventional needle compared to endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) with a Franseen needle for diagnosing lymphadenopathy. Methods. Patients who underwent EUS-FNA or EUS-FNB for mediastinal or abdominal lymphadenopathy between July 2013 and August 2020 were enrolled in the study. The outcomes between EUS-FNA patients (July 2013 to January 2017; 22-gauge conventional needle; Group A) and EUS-FNB patients (February 2017 to August 2020; 22-gauge Franseen needle; Group B) were compared. Results. A total of 154 patients (Group A: 83; Group B: 71) were analyzed. The diagnostic accuracy (differentiating between malignant and benign lesions) was 88.0% (95% confidence interval [CI], 79.2–93.3%) in Group A and 95.8% (95% CI, 88.3–98.8%) in Group B. Group B had high diagnostic accuracy, but there was no difference between the groups (). Group B had significantly fewer passes (median 2, interquartile range (IQR): 2-4) than Group A (median 3, IQR: 3-4) (). No procedural adverse events occurred in either group. Conclusions. Although the diagnostic accuracy between the groups was not statistically significant, EUS-FNB with a Franseen needle provided high diagnostic accuracy and required fewer passes to establish a diagnosis. Thus, EUS-FNB is useful for diagnosing lymphadenopathy.

中文翻译：

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超声内镜引导下细针穿刺与活检装置治疗淋巴结肿大的比较

背景。良性和恶性淋巴结病的准确诊断对于确定适当的治疗和预后很重要。本研究评估了内窥镜超声引导下使用常规针的细针穿刺 (EUS-FNA) 与使用 Franseen 针的内窥镜超声引导下细针活检 (EUS-FNB) 诊断淋巴结病的诊断准确性和实用性。方法。在 2013 年 7 月至 2020 年 8 月期间接受 EUS-FNA 或 EUS-FNB 治疗纵隔或腹部淋巴结肿大的患者被纳入研究。比较 EUS-FNA 患者（2013 年 7 月至 2017 年 1 月；22 号常规针；A 组）和 EUS-FNB 患者（2017 年 2 月至 2020 年 8 月；22 号 Franseen 针；B 组）之间的结果。结果. 共分析了 154 名患者（A 组：83；B 组：71）。A 组的诊断准确性（区分恶性和良性病变）为 88.0%（95% 置信区间 [CI]，79.2-93.3%），B 组为 95.8%（95% CI，88.3-98.8%）。 B 组诊断准确率高，但组间无差异（）。B 组的传球次数（中位数 2，四分位距 (IQR)：2-4）明显少于 A 组（中位数 3，IQR：3-4）（）。两组均未发生程序性不良事件。结论。尽管各组之间的诊断准确性没有统计学意义，但使用 Franseen 针的 EUS-FNB 提供了很高的诊断准确性，并且需要更少的通过次数来建立诊断。因此，EUS-FNB 可用于诊断淋巴结病。