Differentiation potentials of haploid epiblast stem cells (haEpiSCs) into neural lineages, as shown by the yielding neural progenitors (SOX1+, green) and neurons (TUJ1+, red) in vitro with a single genome nature. These unique homozygous pluripotent stem cells are promising in genetic screening of various biological processes, including reprogramming.

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封面

单倍体表皮干细胞（haEpiSCs）分化为神经谱系的潜力，如具有单个基因组性质的体外产生的神经祖细胞（SOX1 +，绿色）和神经元（TUJ1 +，红色）所示。这些独特的纯合性多能干细胞在包括重编程在内的各种生物学过程的遗传筛选中很有前途。