Small leucine rich repeat proteoglycans (SLRPs) are a group of active components of the extracellular matrix in all tissues. SLRPs bind to collagens and regulate collagen fibril growth and fibril organization. SLRPs also interact with various cytokines and extracellular compounds, which lead to various biological functions such cell adhesion and signaling, proliferation, and differentiation. Mutations in SLRP genes are associated with human diseases. Now crystal structures of five SLRPs are available. We describe some features of amino acid sequence and structures of SLRPs. We also review ligand interactions and then discuss the interaction surfaces. Furthermore, we map mutations associated with human diseases and discuss possible effects on structures by the mutations.

富含亮氨酸的小重复蛋白聚糖 (SLRP) 是所有组织中细胞外基质的一组活性成分。SLRP 与胶原蛋白结合并调节胶原纤维生长和纤维组织。SLRP 还与各种细胞因子和细胞外化合物相互作用，从而导致各种生物学功能，如细胞粘附和信号传导、增殖和分化。SLRP 基因的突变与人类疾病有关。现在可以使用五种 SLRP 的晶体结构。我们描述了 SLRP 的氨基酸序列和结构的一些特征。我们还回顾了配体相互作用，然后讨论了相互作用表面。此外，我们绘制了与人类疾病相关的突变图，并讨论了突变对结构的可能影响。