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Arterial pulse wave propagation across stenoses and aneurysms: assessment of one-dimensional simulations against three-dimensional simulations and in vitro measurements
Journal of The Royal Society Interface ( IF 3.7 ) Pub Date : 2021-04-14 , DOI: 10.1098/rsif.2020.0881
Weiwei Jin 1 , Jordi Alastruey 1, 2
Affiliation  

One-dimensional (1-D) arterial blood flow modelling was tested in a series of idealized vascular geometries representing the abdominal aorta, common carotid and iliac arteries with different sizes of stenoses and/or aneurysms. Three-dimensional (3-D) modelling and in vitro measurements were used as ground truth to assess the accuracy of 1-D model pressure and flow waves. The 1-D and 3-D formulations shared identical boundary conditions and had equivalent vascular geometries and material properties. The parameters of an experimental set-up of the abdominal aorta for different aneurysm sizes were matched in corresponding 1-D models. Results show the ability of 1-D modelling to capture the main features of pressure and flow waves, pressure drop across the stenoses and energy dissipation across aneurysms observed in the 3-D and experimental models. Under physiological Reynolds numbers (Re), root mean square errors were smaller than 5.4% for pressure and 7.3% for the flow, for stenosis and aneurysm sizes of up to 85% and 400%, respectively. Relative errors increased with the increasing stenosis and aneurysm size, aneurysm length and Re, and decreasing stenosis length. All data generated in this study are freely available and provide a valuable resource for future research.



中文翻译:

动脉脉搏波在狭窄和动脉瘤中的传播:一维模拟对三维模拟和体外测量的评估

在一系列理想的血管几何形状(代表腹主动脉,颈总动脉和动脉具有不同大小的狭窄和/或动脉瘤)中测试了一维(1-D)动脉血流模型。三维(3-D)建模和体外测量被用作地面真相,以评估一维模型压力和流量波的准确性。一维和三维配方具有相同的边界条件,并且具有相同的血管几何形状和材料特性。在不同的一维模型中,针对不同动脉瘤大小的腹主动脉实验装置的参数进行了匹配。结果表明,一维建模能够捕获压力和流量波的主要特征,狭窄部位的压降以及在3D模型和实验模型中观察到的整个动脉瘤的能量耗散。在生理雷诺数(),对于狭窄和动脉瘤大小分别高达85%和400%的情况,均方根误差小于5.4%的压力和7.3%的流量。相对误差随着狭窄和动脉瘤大小,动脉瘤长度和Re的增加以及狭窄长度的减少而增加。本研究生成的所有数据均可免费获得,并为将来的研究提供了宝贵的资源。

更新日期:2021-04-14
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