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Metabolic stroke-like episode in a child with FARS2 mutation and SARS-CoV-2 positive cerebrospinal fluid
Molecular Genetics and Metabolism Reports ( IF 1.9 ) Pub Date : 2021-04-14 , DOI: 10.1016/j.ymgmr.2021.100756
Kelly T. Powers , Jonathan D. Santoro

The novel SARS-CoV-2 has infected over 48 million persons around the world. Children have been spared with regards to symptoms and sequelae of this highly infectious virus and in those with neurologic issues, the virus has not been present in the cerebrospinal fluid. Here, the authors present the first case of metabolic stroke-like episode with SARS-CoV-2 present in the cerebrospinal fluid in a child with a FARS2 deficiency. This report suggests a possible association of SARS-COV-2 infection and metabolic stroke-like episode, even in the absence of a phenotype classically associated with metabolic stroke-like episodes.



中文翻译:

患有FARS2突变和SARS-CoV-2阳性脑脊液的儿童代谢性中风样发作

新颖的SARS-CoV-2病毒已感染全球超过4800万人。在这种高度传染性病毒的症状和后遗症方面,儿童已幸免于难;在患有神经系统疾病的儿童中,脑脊液中不存在该病毒。在此,作者介绍了首例患有FARS2缺乏症儿童的脑脊液中出现SARS-CoV-2的代谢性中风样发作。该报告表明,即使没有经典的与代谢性中风样发作相关的表型,SARS-COV-2感染也可能与代谢性中风样发作相关。

更新日期:2021-04-20
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