Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease (PD) also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients were classified as cognitively normal (PD-NC) or mildly impaired (PD-MCI) according to Level I consensus criteria, and assessed using a comprehensive neuropsychological test battery, neurological motor examination, and sociodemographic and clinical questionnaires. In total, 18% showed arithmetic deficits: they were predominately female, had longer disease duration, more impaired global cognition, but minor signs of depression compared to PD patients without arithmetic deficits. When correcting for clinical and sociodemographic confounders, greater impairments in attention and visuo-spatial/constructional domains predicted occurrence of arithmetic deficits. The type of deficit did not seem to be arbitrary but seemed to involve impaired place × value processing frequently. Our results argue for the importance of further systematic investigations of arithmetic deficits in PD with sensitive tests to confirm the results of our exploratory study that a specific subgroup of PD patients present themselves with dyscalculia.

尽管计算障碍对患者的独立性和日常生活功能活动有很大影响，但对神经退行性疾病中计算障碍的研究仍然很少。大多数研究都是针对阿尔茨海默病；然而，帕金森病 (PD) 患者出现认知障碍的风险也较高，而其与财务背景下的算术缺陷的关系却很少被研究。因此，当前的探索性研究调查了 100 名帕金森病患者在临床痴呆评级中管理的财务背景下两项简单算术任务的缺陷。根据 I 级共识标准，将患者分为认知正常 (PD-NC) 或轻度受损 (PD-MCI)，并使用综合神经心理学测试、神经运动检查以及社会人口统计学和临床​​问卷进行评估。总共有 18% 的患者表现出算术缺陷：与没有算术缺陷的 PD 患者相比，她们主要是女性，病程较长，整体认知受损更严重，但抑郁症状较轻。当纠正临床和社会人口统计学的混杂因素时，注意力和视觉空间/结构领域的更大损害预示着算术缺陷的发生。缺陷的类型似乎不是任意的，但似乎经常涉及位置×价值处理受损。我们的结果证明了通过敏感测试对 PD 算术缺陷进行进一步系统研究的重要性，以证实我们探索性研究的结果，即 PD 患者的特定亚组出现计算障碍。