Long non-coding RNAs (lncRNAs) have been proposed as promising diagnostic and prognostic biomarkers for cancer. We investigated the associations of RNA polymerase II subunit E (POLR2E) rs3787016 polymorphism with the risk and prognosis of gastric cancer (GC). The study subjects included 368 GC patients who underwent surgical resection and 294 healthy volunteers, adjusted for age, gender, smoking status, alcohol status, and Helicobacter pylori infection status. The data was subjected to logistic regression analyses and revealed that the subjects carrying AA genotype of rs3787016 in POLR2E had a significant 1.85-1.98-fold increased risk of GC when compared with those carrying GG genotype (adjusted OR = 1.979, 95% CI = 1.198-3.267; p = 0.008) or those carrying AG/GG genotypes (adjusted OR = 1.847, 95% CI = 1.222-2.793; p = 0.004). For the GC patients, the AA genotype of rs3787016 was significantly correlated with poorly differentiated GC (p = 0.018), advanced TNM stage (p = 0.023), higher depth of invasion (p = 0.022), positive lymph node metastasis (p = 0.01), and worse overall survival (OS; p = 0.004). Multivariate analysis confirmed that the POLR2E rs3787016 polymorphism is an independent prognostic factor for GC (HR = 1.668, 95% CI = 1.058-2.631; p = 0.028). Our cumulative results thus suggest that the presence of POLR2E rs3787016 polymorphism could serve as a genetic factor that affects the susceptibility to and the prognosis of GC.

中文翻译：

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POLR2E rs3787016多态性与胃癌的易感性和预后有关。

长非编码RNA（lncRNA）已被提出作为有希望的癌症诊断和预后生物标志物。我们调查了RNA聚合酶II亚基E（POLR2E）rs3787016多态性与胃癌（GC）的风险和预后的关系。研究对象包括368例行手术切除的GC患者和294例健康志愿者，这些患者经过了年龄，性别，吸烟状况，酒精状况和幽门螺杆菌感染状况的调整。对该数据进行了逻辑回归分析，结果表明，与携带GG基因型的受试者相比，在POLR2E中携带AA基因型的rs3787016的受试者与罹患GG基因型的受试者相比，GC风险显着提高了1.85-1.98倍（调整后的OR = 1.979，95％CI = 1.198 -3.267； p = 0.008）或携带AG / GG基因型的患者（调整后的OR = 1.847，95％CI = 1.222-2.793； p = 0.004）。对于GC患者，rs3787016的AA基因型与低分化GC（p = 0.018），晚期TNM分期（p = 0.023），浸润深度（p = 0.022），淋巴结转移阳性（p = 0.01）和总体较差显着相关生存率（OS; p = 0.004）。多变量分析证实POLR2E rs3787016多态性是GC的独立预后因素（HR = 1.668，95％CI = 1.058-2.631； p = 0.028）。因此，我们的累积结果表明POLR2E rs3787016多态性的存在可以作为影响GC易感性和预后的遗传因素。多变量分析证实POLR2E rs3787016多态性是GC的独立预后因素（HR = 1.668，95％CI = 1.058-2.631； p = 0.028）。因此，我们的累积结果表明POLR2E rs3787016多态性的存在可以作为影响GC易感性和预后的遗传因素。多变量分析证实POLR2E rs3787016多态性是GC的独立预后因素（HR = 1.668，95％CI = 1.058-2.631； p = 0.028）。因此，我们的累积结果表明POLR2E rs3787016多态性的存在可以作为影响GC易感性和预后的遗传因素。