Background: Reactive gastropathy (RG) is an adaptive response to assaults of the gastric mucosa. Demographic information regarding RG as well as the coincidence of RG and gastrointestinal cancer are poorly characterized entities. Objective: Herein, we aim to investigate relationships of RG to both modifiable and nonmodifiable risk factors, as well as conduct a stratified analysis by race in an ethnically diverse, urban population. Methods: In this retrospective study, we queried an urban hospital inpatient pathology database searching for patients with surgical gastric biopsies positive for RG between March 25, 2015, and March 25, 2016. Of the 728 patients with a final diagnosis of RG, 292 were selected based on strict inclusion and exclusion criteria. We explored risk factors and conducted a stratified analysis for associations based on patient demographics. Results: In this urban minority population, nonsteroidal anti-inflammatory drugs (NSAIDs) were the most common medication associated with RG (Fig. 1), as well as the most common cause of RG, followed by chronic bile reflux. In addition, significant differences in demographics and gastropathic characteristics associated with RG, stratified by ethnicity, were found (Fig. 2). Notably, Hispanics, African Americans, and Caucasians had the highest rate of concomitant RG and diabetes, hypertension, and tobacco/alcohol use, respectively. Conclusion: Our study indicated that NSAID usage is the most common cause of RG, followed by bile reflux-mediated mucosal injury, in an ethnically diverse urban US-based population. Of note, few patients had intestinal metaplasia, suggesting it to be a slow or negligent sequela of RG.
Gastrointest Tumors

中文翻译：

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城市人口反应性胃病的病因分析

背景：反应性胃病（RG）是对胃粘膜侵袭的一种适应性反应。有关RG的人口统计学信息以及RG与胃肠道癌的巧合是特征不明确的实体。目的：在本文中，我们旨在调查RG与可修改和不可修改风险因素的关系，并对种族多样化的城市人口进行种族分类分析。方法：在这项回顾性研究中，我们查询了城市医院的住院病理数据库，以寻找2015年3月25日至2016年3月25日期间RG阳性的手术胃活检患者。在728例最终诊断为RG的患者中，选择了292例根据严格的纳入和排除标准。我们探索了危险因素，并根据患者人口统计学特征对相关性进行了分层分析。结果：在这个城市少数民族中，非甾体类抗炎药（NSAIDs）是与RG相关的最常见药物（图1），也是RG的最常见病因，其次是慢性胆汁反流。此外，还发现按族裔分层的与RG相关的人口统计学和胃病特征存在显着差异（图2）。值得注意的是，西班牙裔，非洲裔美国人和高加索人分别具有最高的RG和糖尿病，高血压和烟草/烟酒使用率。结论：我们的研究表明，在美国多种族的城市人群中，使用NSAID是导致RG的最常见原因，其次是胆汁反流介导的粘膜损伤。值得注意的是，很少有患者出现肠上皮化生，提示它是RG的缓慢或疏忽性后遗症。
胃肠道肿瘤