NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca²⁺ from endolysosomes through two-pore channels (TPCs) and from the endoplasmic reticulum (ER) through type 1 ryanodine receptors (RyR1). How NAADP activates these channels, whether directly or indirectly, has been a matter of debate for more than a decade. Now a protein has emerged possibly providing the missing link between TPCs/RyR1 and NAADP.

中文翻译：

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JPT2：细胞内 Ca2+ 释放通道和 NAADP 之间缺失的联系？

NAADP（烟酸腺嘌呤二核苷酸磷酸）是一种有效的第二信使，通过双孔通道 (TPC) 从内溶酶体释放 Ca ²⁺ ，并通过 1 型兰尼碱受体 (RyR1) 从内质网 (ER) 释放 Ca 2+。 NAADP 如何直接或间接激活这些渠道，十多年来一直是一个争论的问题。现在，一种蛋白质的出现可能提供了 TPCs/RyR1 和 NAADP 之间缺失的联系。