ABSTRACT

Background

Oxidative stress is the result of cellular troubles related to aerobic metabolism. Furthermore, this stress is always associated with biological responses evoked by physical, chemical, environmental, and psychological factors. Several studies have developed many approaches of antioxidant defense to diminish the severity of many diseases. Ghrelin was originally identified from the rat stomach, and it is a potent growth hormone-releasing peptide that has pleiotropic functions.

Methods

A systematic review was conducted within PubMed, ScienceDirect, MEDLINE, and Scopus databases using keywords such as ghrelin, antioxidant, oxidative stress, and systemic oxidative stress sensor.

Results

In the last decade, many studies show that ghrelin exhibits protection effects against oxidative stress derived probably from its antioxidant effects. Pieces of evidence demonstrate that systemic oxidative stress increase ghrelin levels in the plasma. The expression of ghrelin and its receptor in ghrelin peripheral tissues and extensively in the central nervous system suggests that this endogenous peptide plays an important role as a systemic oxidative stress sensor

Conclusion

The current evidence confirms that ghrelin and its derived peptides (Desacyl-ghrelin, obestatin) act as a protective antioxidant agent. Therefore, stressor modality, duration, and intensity are the parameters of oxidative stress that must be taken into consideration to determine the role of ghrelin, Desacyl-ghrelin, and obestatin in the regulation of cell death pathways.

中文翻译：

---

生长素释放肽作为抗氧化剂和保护剂的潜力

摘要

背景

氧化应激是与有氧代谢相关的细胞问题的结果。此外，这种压力总是与物理、化学、环境和心理因素引起的生物反应有关。几项研究已经开发出许多抗氧化防御方法来降低许多疾病的严重程度。Ghrelin 最初是从大鼠胃中发现的，它是一种具有多效性的强效生长激素释放肽。

方法

在 PubMed、ScienceDirect、MEDLINE 和 Scopus 数据库中使用生长素释放肽、抗氧化剂、氧化应激和全身氧化应激传感器等关键词进行了系统评价。

结果

在过去的十年中，许多研究表明，生长素释放肽对可能源自其抗氧化作用的氧化应激具有保护作用。一些证据表明，全身性氧化应激会增加血浆中的生长素释放肽水平。ghrelin 及其受体在 ghrelin 外周组织和中枢神经系统中的广泛表达表明，这种内源性肽作为全身氧化应激传感器发挥着重要作用

结论

目前的证据证实，ghrelin 及其衍生肽（Desacyl-ghrelin，obestatin）可作为保护性抗氧化剂。因此，应激源形式、持续时间和强度是氧化应激的参数，必须考虑这些参数以确定生长素释放肽、脱乙酰-生长素释放肽和肥胖抑制素在细胞死亡途径调节中的作用。