Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD.

Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings "COPD" and "Fatigue". Studies were reviewed in accordance with PRISMA guidelines.

196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=–0.23 to r=0.27), sex (r=0.11), marital status (r=–0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=–0.55 to r=–0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=–0.78 to r=–0.45), functional capacity (r=–0.77 to r=–0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue.

Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.

疲劳是 COPD 患者的一种痛苦症状。关于导致 COPD 疲劳的因素知之甚少。这篇综述总结了关于疲劳患病率、疲劳相关因素以及最常用于评估 COPD 疲劳的仪器的现有知识。

使用医学主题词“COPD”和“疲劳”搜索 Pubmed、PsycINFO、EMBASE、Cochrane 和 CINAHL 数据库中从开始到 2020 年 1 月 7 日的研究。根据 PRISMA 指南对研究进行了审查。

评估了 196 项研究。疲劳的患病率在 17-95% 之间。年龄（r=–0.23 至 r=0.27）、性别（r=0.11）、婚姻状况（r=–0.096）、呼吸困难（r=0.13 至 r=0.78）、1 秒内用力呼气量百分比预测值（r= –0.55 至 r=–0.076），恶化次数（r=0.27 至 r=0.38），合并症次数（r=0.10），药物次数（r=0.35），焦虑（r=0.36 至 r=0.61） 、抑郁（r=0.41 至 r=0.66）、肌肉力量（r=–0.78 至 r=–0.45）、功能能力（r=–0.77 至 r=–0.14）和生活质量（r=0.48 至 r= 0.77) 与疲劳显着相关。

疲劳是 COPD 患者的普遍症状。多种身体和心理因素似乎与疲劳有关。未来的研究需要在 COPD 患者样本的整体分析中评估这些潜在因素。