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Ventilation/carbon dioxide output relationships during exercise in health
European Respiratory Review ( IF 9.0 ) Pub Date : 2021-04-13 , DOI: 10.1183/16000617.0160-2020
Susan A Ward 1
Affiliation  

"Ventilatory efficiency" is widely used in cardiopulmonary exercise testing to make inferences regarding the normality (or otherwise) of the arterial CO2 tension (PaCO2) and physiological dead-space fraction of the breath (VD/VT) responses to rapid-incremental (or ramp) exercise. It is quantified as: 1) the slope of the linear region of the relationship between ventilation (V'E) and pulmonary CO2 output (V'CO2); and/or 2) the ventilatory equivalent for CO2 at the lactate threshold (V'E/V'CO2 ) or its minimum value (V'E/V'CO2min), which occurs soon after but before respiratory compensation. Although these indices are normally numerically similar, they are not equally robust. That is, high values for V'E/V'CO2 and V'E/V'CO2min provide a rigorous index of an elevated VD/VT when PaCO2 is known (or can be assumed) to be regulated. In contrast, a high V'EV'CO2 slope on its own does not, as account has also to be taken of the associated normally positive and small V'E intercept. Interpretation is complicated by factors such as: the extent to which PaCO2 is actually regulated during rapid-incremental exercise (as is the case for steady-state moderate exercise); and whether V'E/V'CO2 or V'E/V'CO2min provide accurate reflections of the true asymptotic value of V'E/V'CO2, to which the V'EV'CO2 slope approximates at very high work rates.



中文翻译:

健康运动过程中的通气/二氧化碳输出关系

“通气效率”广泛用于心肺运动测试,以推断动脉 CO 2张力 ( P aCO 2 ) 和呼吸的生理死腔分数 ( V D / V T ) 的正常(或其他)反应快速增量(或斜坡)运动。量化为: 1)通气量(V'E与肺CO 2输出量(V'CO 2 )线性区域的斜率;和/或 2) CO 2在乳酸阈值 ( V 'E / V'CO 2 _ _ ) 或其最小值 ( V ' E / V ' CO 2分钟), 其发生后不久 但在呼吸代偿之前。尽管这些指数通常在数值上相似,但它们并不同样稳健。也就是说,V ' E / V ' CO 2的值很高 V ' E / V ' CO 2 min 提供了当已知(或可以假定)要调节PaCO 2升高的V D / V T的严格指标。相比之下,高V ' EV ' CO 2斜率本身不会,因为还必须考虑相关的通常为正的和小的V ' E截距。解释因以下因素而变得复杂:P aCO 2实际上在快速增量运动期间受到调节(如稳态适度运动的情况);以及是否V ' E / V ' CO 2 V ' E / V ' CO 2分钟提供V ' E / V ' CO 2的真实渐近值的准确反映,V ' E V ' CO 2斜率在非常高的工作率下接近该值。

更新日期:2021-04-14
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