The overweight and obese population has skyrocketed, resulting in a high incidence of metabolic disorders. Agardhiella subulata (AS) contains a variety of beneficial components, such as sulfur-containing polysaccharides (dietary fiber) and astaxanthin, which is considered to have anti-obesity potential. In this study, we investigated the effects and possible mechanisms of dietary AS on high-fat diet (HFD)-induced obesity in mice. AS supplementation significantly reduced HFD-induced weight gain (19%) and the visceral adiposity index (4.1%). In addition, the level of total cholesterol, triglyceride, and low-density lipoprotein was significantly decreased; adiponectin was significantly increased in serum and fecal triglyceride excretion was significantly higher in mice fed AS compared with mice on an HFD. Preadipocyte factor 1 and Sry-box transcription factor 9 that were significantly higher than the levels found for the HFD group lead to reduced adipogenesis. Moreover, accompanying the lipolysis and fatty acid β-oxidation that occur in the AS group, the concentration of non-esterified fatty acids was lowered to 0.4 ± 0.1 mEq/L. In addition, peroxisome proliferator-activated receptor γ and phosphorylation acetyl-CoA carboxylase increased 1.5- and 1-fold, thus increasing the expression of adiponectin and the activation of AMPK and ultimately resulting in lower blood glucose levels. The results of this study suggest that AS supplementation increases lipid excretion and improves energy metabolism to prevent obesity in mice fed a HFD.

中文翻译：

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饲喂高脂饮食的Subardata subulata抗肥胖特性的分子机制

超重和肥胖人口激增，导致代谢紊乱的发生率很高。枯草杆菌（AS）包含多种有益成分，例如含硫多糖（膳食纤维）和虾青素，被认为具有抗肥胖的潜力。在这项研究中，我们调查了饮食中AS对高脂饮食（HFD）诱发的小鼠肥胖的影响及其可能的机制。补充AS可以显着降低HFD引起的体重增加（19％）和内脏脂肪指数（4.1％）。此外，总胆固醇，甘油三酸酯和低密度脂蛋白的水平显着降低；与使用HFD的小鼠相比，用AS喂养的小鼠的血清脂联素显着增加，而粪便甘油三酸酯的排泄显着更高。脂肪细胞因子1和Sry-box转录因子9明显高于HFD组的水平，导致脂肪生成减少。而且，伴随AS组中发生的脂解和脂肪酸β-氧化，非酯化脂肪酸的浓度降低至0.4±0.1 mEq / L。此外，过氧化物酶体增殖物激活受体γ和磷酸化乙酰辅酶A羧化酶增加了1.5倍和1倍，从而增加了脂联素的表达和AMPK的活化，最终导致血糖水平降低。这项研究的结果表明，补充AS可以增加高脂饮食小鼠的脂质排泄并改善能量代谢，从而预防肥胖。因此增加了脂联素的表达和AMPK的激活，最终导致血糖水平降低。这项研究的结果表明，补充AS可以增加高脂饮食小鼠的脂质排泄并改善能量代谢，从而预防肥胖。因此增加了脂联素的表达和AMPK的激活，最终导致血糖水平降低。这项研究的结果表明，补充AS可以增加高脂饮食小鼠的脂质排泄并改善能量代谢，从而预防肥胖。