People with autism spectrum disorder (ASD) exhibit a variety of medical morbidities at significantly higher rates than the general population. Using an established monkey model of naturally occurring low sociality, we investigated whether low-social monkeys show an increased burden of medical morbidities compared to their high-social counterparts. We systematically reviewed the medical records of N = 152 (n = 73 low-social; n = 79 high-social) rhesus macaques (Macaca mulatta) to assess the number of traumatic injury, gastrointestinal, and inflammatory events, as well as the presence of rare medical conditions. Subjects' nonsocial scores, determined by the frequency they were observed in a nonsocial state (i.e., alone), and macaque Social Responsiveness Scale-Revised (mSRS-R) scores were also used to test whether individual differences in social functioning were related to medical morbidity burden. Medical morbidity type significantly differed by group, such that low-social monkeys incurred higher rates of traumatic injury compared to high-social monkeys. Nonsocial scores and mSRS-R scores also significantly and positively predicted traumatic injury rates, indicating that monkeys with the greatest social impairment were most impacted on this health measure. These findings from low-social monkeys are consistent with well-documented evidence that people with ASD incur a greater number of traumatic injuries and receive more peer bullying than their neurotypical peers, and add to growing evidence for the face validity of this primate model.

中文翻译：

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在自然发生的低社会性恒河猴模型中评估医学发病率

自闭症谱系障碍 (ASD) 患者表现出各种医学疾病，其发病率明显高于普通人群。使用已建立的自然发生的低社会性猴子模型，我们调查了与高社会性的猴子相比，低社会性的猴子是否表现出增加的医疗疾病负担。我们系统地回顾了N = 152 ( n = 73 低社交；n = 79 高社交) 恒河猴 ( Macaca mulatta) 以评估外伤、胃肠道和炎症事件的数量，以及是否存在罕见的医疗状况。受试者的非社会分数，由他们在非社会状态（即单独）中观察到的频率决定，以及猕猴社会反应量表修订版（mSRS-R）分数也用于测试社会功能的个体差异是否与医疗相关发病负担。不同组的医学发病率类型显着不同，因此与高社交猴子相比，低社交猴子的创伤率更高。非社会性评分和 mSRS-R 评分也显着且积极地预测了创伤性损伤率，表明具有最大社会性损伤的猴子对这一健康指标的影响最大。