Suicide is commonly found in patients with major depressive disorder (MDD), while the associations among depressive symptoms and their relationships with suicidal risk remain unclear. This study identified the symptoms associated with suicidal risk and the most central symptoms in the MDD networks based on both self-reported and clinical-interview scales. A total of 446 outpatients with MDD were recruited. The Mini International Neuropsychiatric Interview (MINI) was used to assess the suicidal risk. The 13-item Beck Depression Inventory (BDI-13) and 17-item Hamilton Depression Rating Scale (HAMD-17) were used to measure the depressive symptoms. Network analysis was used to estimate the network models. Ten symptoms in the BDI-13 network were related to suicidal risk, among which sadness had the strongest association. Among the six symptoms in the HAMD-17 network that were associated with suicidal risk, guilty feeling was the strongest. Sense of failure was the most central symptom in the BDI-13 network, while depressed mood had the highest centrality in the HAMD-17 network. The depressive symptoms related to suicide risk and the clinical features of MDD showed different characteristics based on different assessment types. Combining self-reported and clinician-rated assessments in future studies and clinical practice might lead to some new findings.

中文翻译：

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抑郁症状与自杀风险之间的关联：基于网络视角的自我报告和临床访谈测量

自杀常见于重度抑郁症 (MDD) 患者，而抑郁症状之间的关联及其与自杀风险的关系仍不清楚。本研究根据自我报告和临床访谈量表确定了与自杀风险相关的症状和 MDD 网络中最核心的症状。共招募了 446 名 MDD 门诊患者。迷你国际神经精神病学访谈（MINI）用于评估自杀风险。13项贝克抑郁量表（BDI-13）和17项汉密尔顿抑郁量表（HAMD-17）用于测量抑郁症状。网络分析用于估计网络模型。BDI-13 网络中的 10 个症状与自杀风险相关，其中悲伤的关联性最强。在 HAMD-17 网络中与自杀风险相关的六种症状中，内疚感最强。失败感是 BDI-13 网络中最中心的症状，而抑郁情绪在 HAMD-17 网络中具有最高的中心性。与自杀风险相关的抑郁症状和MDD的临床特征根据不同的评估类型表现出不同的特征。在未来的研究和临床实践中结合自我报告和临床医生评定的评估可能会导致一些新的发现。与自杀风险相关的抑郁症状和MDD的临床特征根据不同的评估类型表现出不同的特征。在未来的研究和临床实践中结合自我报告和临床医生评定的评估可能会导致一些新的发现。与自杀风险相关的抑郁症状和MDD的临床特征根据不同的评估类型表现出不同的特征。在未来的研究和临床实践中结合自我报告和临床医生评定的评估可能会导致一些新的发现。