Numerous national guidelines now include primary human papillomavirus (HPV) testing as a recommended screening option for cervical cancer in the United States yet little is known regarding screening intentions for this specific screening strategy or interventions that may increase uptake. Gain- and loss-framed messaging can positively impact health behaviors; however, there is mixed evidence on which is more effective for cervical cancer screening, with no published evidence examining HPV testing. To help address this gap, this study compared the effects of message framing on screening knowledge and intentions related to primary HPV testing. We randomized females aged 21–65 ( n = 365) to receive brief messaging about cervical cancer screening with either gain- or loss-framing. In January–February 2020, participants completed pretest and posttest measures evaluating cervical cancer knowledge, beliefs, and intentions to be screened using HPV testing. We used generalized estimating equations to model message and framing effects on screening outcomes, controlling for age, education, race, and baseline measures. In comparison to pretest, messaging significantly increased HPV-related screening intentions [adjusted OR (aOR): 2.4 (1–3.5)] and knowledge [aOR: 1.7 (1.2–2.4)], perceived effectiveness of HPV testing [aOR: 4.3 (2.8–6.5)], and preference for primary HPV screening [aOR: 3.2 (1.2–8.5)], regardless of message framing. For all outcomes, no significant interaction by message framing was observed. Brief public health messaging positively impacted HPV-related screening intentions, knowledge, and beliefs, independent of message framing. In conjunction with other strategies, these results suggest that messaging could be an effective tool to increase uptake of primary HPV testing. Prevention Relevance: Primary HPV tests are more sensitive and offer greater reassurance than Pap tests alone yet use for routine cervical cancer screening remains low. Brief public health messaging can positively impact awareness, knowledge, and screening intention regarding primary HPV testing. Messaging campaigns paired with other strategies can increase uptake across populations. See related Spotlight, [p. 823][1] [1]: /lookup/volpage/14/823?iss=9

中文翻译：

---

信息框架对宫颈癌筛查知识和原发性 HPV 检测意图的影响

许多国家指南现在将原发性人乳头瘤病毒 (HPV) 检测作为美国宫颈癌的推荐筛查选择，但对于这种特定筛查策略或可能增加摄取的干预措施的筛查意图知之甚少。收益和损失框架信息可以对健康行为产生积极影响；然而，关于哪种对宫颈癌筛查更有效的证据不一，没有公布的证据检查 HPV 检测。为了帮助解决这一差距，本研究比较了信息框架对与初级 HPV 检测相关的筛查知识和意图的影响。我们随机分配了 21-65 岁的女性（n = 365），以接收有关宫颈癌筛查的简短信息，包括增益或损失框架。2020 年 1 月至 2 月，参与者完成了评估宫颈癌知识、信念和使用 HPV 检测进行筛查的意图的前测和后测测量。我们使用广义估计方程来模拟信息和框架对筛选结果的影响，控制年龄、教育、种族和基线测量。与预测试相比，消息传递显着增加了 HPV 相关筛查意图 [调整后的 OR (aOR): 2.4 (1-3.5)] 和知识 [aOR: 1.7 (1.2-2.4)]，感知 HPV 检测的有效性 [aOR: 4.3 ( 2.8–6.5)]，以及对初级 HPV 筛查的偏好 [aOR: 3.2 (1.2–8.5)]，无论信息框架如何。对于所有结果，没有观察到消息框架的显着交互。简短的公共卫生信息对与 HPV 相关的筛查意图、知识和信念产生积极影响，与信息框架无关。结合其他策略，这些结果表明信息传递可能是增加初级 HPV 检测吸收的有效工具。预防相关性：原发性 HPV 检测比单独的巴氏检测更敏感，提供更大的保证，但用于常规宫颈癌筛查的比例仍然很低。简短的公共卫生信息可以对初级 HPV 检测的认识、知识和筛查意图产生积极影响。与其他策略相结合的消息传递活动可以增加整个人群的接受度。参见相关的 Spotlight，[p. 823][1][1]：/lookup/volpage/14/823?iss=9 与单独的巴氏试验相比，初级 HPV 检测更敏感，也更能提供保证，但用于常规宫颈癌筛查的比例仍然很低。简短的公共卫生信息可以对初级 HPV 检测的认识、知识和筛查意图产生积极影响。与其他策略相结合的消息传递活动可以增加整个人群的接受度。参见相关的 Spotlight，[p. 823][1][1]：/lookup/volpage/14/823?iss=9 与单独的巴氏试验相比，初级 HPV 检测更敏感，也更能提供保证，但用于常规宫颈癌筛查的比例仍然很低。简短的公共卫生信息可以对初级 HPV 检测的认识、知识和筛查意图产生积极影响。与其他策略相结合的消息传递活动可以增加整个人群的接受度。参见相关的 Spotlight，[p. 823][1][1]：/lookup/volpage/14/823?iss=9