COVID‐19 leads to severe respiratory problems, but also to long‐COVID syndrome associated primarily with cognitive dysfunction and fatigue. Long‐COVID syndrome symptoms, especially brain fog, are similar to those experienced by patients undertaking or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS). The pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus. These processes could be mitigated by phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin.

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与长COVID综合征相关的脑雾和化学霜剂：木犀草素的抢救

COVID-19会导致严重的呼吸问题，但也会导致主要与认知功能障碍和疲劳有关的长期COVID综合征。长期COVID综合征的症状，尤其是脑雾，类似于正在接受或化疗后的癌症患者（chemofog或chemobrain）以及患有肌性脑脊髓炎/慢性疲劳综合征（ME / CFS）或肥大细胞活化综合征的患者（MCAS）。在这些疾病中，脑雾的发病机理目前尚不清楚，但可能涉及通过由病原体和应激刺激刺激的肥大细胞释放出激活小胶质细胞并导致下丘脑发炎的介质而引起的神经炎症。天然黄酮类木犀草素的植物体制剂（在橄榄果渣油中）可以减轻这些过程。