Clozapine may cause life-threatening hematological side effects (HSEs). Hematological side effect incidence data from Sub-Saharan Africa are lacking. Furthermore, clozapine reduces cellular immunity, and it is unknown whether clozapine is a risk factor for tuberculosis or whether HIV is a risk factor for developing HSEs. We assessed the incidence of HSEs in South Africans from the Western Cape Province on clozapine, and the secondary objective was to determine the association of HIV and tuberculosis with clozapine exposure.

中文翻译：

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南非西开普的氯氮平相关白细胞减少症和粒细胞缺乏症：一项为期 3 年的回顾性队列研究。

氯氮平可能会导致危及生命的血液学副作用 (HSE)。缺乏来自撒哈拉以南非洲的血液学副作用发生率数据。此外，氯氮平会降低细胞免疫，目前尚不清楚氯氮平是否是结核病的危险因素，或者 HIV 是否是发生 HSE 的危险因素。我们评估了西开普省南非人使用氯氮平的 HSE 发生率，次要目标是确定 HIV 和结核病与氯氮平暴露之间的关联。