Continuing to eat even when full leads to excessive calorie consumption and obesity. Thus, understanding brain responses to food cues when satiated has important implications for weight control interventions. We used the late positive potential (LPP, a component of the event-related potentials (ERP) indexing motivational relevance) to determine the extent to which satiety affects brain responses to images of highly palatable foods (high-fat, high-sugar), high and low motivationally relevant (pleasant, unpleasant) and neutral stimuli in a sample of obese (body mass index [BMI] ≥ 30 kg/m2) and lean (BMI < 25 kg/m2) individuals. Satiated individuals (N = 55, 21 with BMI ≥ 30 kg/m2) were fed a nutritional drink prior to the experimental session and were individually matched with 55 unsatiated individuals who saw the same images during a passive viewing task. Satiety did not affect LPP response to food-related or motivationally relevant cues in either BMI < 25 kg/m2 or BMI ≥ 30 kg/m2 individuals (p = .6). Irrespective of satiety, all participants showed larger LPPs as a function of the images' motivational relevance. There were no differences in LPP amplitude between BMI < 25 kg/m2 and BMI ≥ 30 kg/m2 individuals for any picture category, including food. However, within-group comparisons showed that BMI < 25 kg/m2 individuals had larger LPPs to low motivationally relevant pleasant images than to food-related cues (p < .001); this difference was not significant for BMI ≥ 30 kg/m2 individuals. Although satiety does not affect LPP responses to food-related cues, these results highlight the importance of evaluating reactivity to food-related cues in relation to other motivationally relevant stimuli. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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饱腹感不影响对食物相关或情绪视觉线索的神经情感电生理反应。

即使吃饱了仍继续进食会导致卡路里消耗过多和肥胖。因此，了解饱足时大脑对食物线索的反应对体重控制干预具有重要意义。我们使用晚期正电位（LPP，事件相关电位 (ERP) 索引动机相关性的一个组成部分）来确定饱腹感在多大程度上影响大脑对高度可口食物（高脂肪、高糖）图像的反应，肥胖（体重指数 [BMI] ≥ 30 kg/m2）和瘦（BMI < 25 kg/m2）个体样本中的高和低动机相关（愉快、不愉快）和中性刺激。满足的个体 ( N= 55, 21 名 BMI ≥ 30 kg/m2）在实验前被喂食营养饮料，并与 55 名在被动观看任务中看到相同图像的不满足的人单独匹配。在 BMI < 25 kg/m2 或 BMI ≥ 30 kg/m2 的个体中，饱腹感不影响 LPP 对食物相关或动机相关线索的反应 ( p = .6)。无论饱腹感如何，所有参与者都显示出较大的 LPP，作为图像动机相关性的函数。对于任何图片类别（包括食物），BMI < 25 kg/m2 和 BMI ≥ 30 kg/m2 的个体之间的 LPP 幅度没有差异。然而，组内比较表明，BMI < 25 kg/m2 的个体对低动机相关的愉快图像的 LPP 大于食物相关线索（p< .001); 对于 BMI ≥ 30 kg/m2 的个体，这种差异并不显着。虽然饱腹感不会影响 LPP 对食物相关线索的反应，但这些结果强调了评估与其他动机相关刺激相关的食物相关线索的反应性的重要性。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。