Significant changes in composition of rainbow trout Oncorhynchus mykiss blood cells types were induced after 4-days exposure with mixture of Cu²⁺ and Zn²⁺ at 0.25, 0.125 and 0.06 parts of LC₅₀ in comparison to control group. The highest concentration of metal mixture (0.25 of LC₅₀) significantly induced elevation of the number of monocytes and poly-segmented neutrophils. Treatment with 0.125 parts of LC₅₀ concentration increased the number of thrombocytes, monocytes and non-segmented neutrophils. The most diluted mixture resulted in significant induction of thrombocytes, monocytes, non- and poly segmented neutrophils. Analysis of leucocyte cell types in the O. mykiss blood samples after 4-days of exposure at all applied mixture parts showed signs of monocytosis and neutrophilia. Comparison of different types of leucocytes’ percentages (leukogram) in fish after 4-days exposure to metal mixture and after 4, 8, and 12-days recovery periods showed that, values of neutrophils even after the 12-days recovery period at all tested parts of LC₅₀, and monocytes after exposure with the highest (0.25) used part of LC₅₀ were not restored to control group levels. Depuration and recovery processes in treated fish are concentration and recovery period dependent.

与对照组相比，在0.25、0.125和0.06份LC _50下暴露2天的Cu ²⁺和Zn ^2+的混合物暴露4天后，虹鳟Mykiss血细胞类型的组成发生了显着变化。金属混合物的最高浓度（LC _50的0.25 ）显着诱导了单核细胞和多节段中性粒细胞数量的增加。用0.125份LC ₅₀浓度处理可增加血小板，单核细胞和非节段中性粒细胞的数量。稀释度最高的混合物可显着诱导血小板，单核细胞，非节段和多节段的中性粒细胞。在白细胞的细胞类型的分析O.鳟在所有应用的混合物部位接触4天后，血液样本均显示出单核细胞增多和嗜中性粒细胞增多的迹象。比较暴露于金属混合物4天后，恢复期4、8和12天后鱼中不同类型白细胞的百分比（白血球），结果表明，在所有测试中，中性粒细胞的值即使在恢复12天后也是如此LC的部件₅₀，和曝光具有最高（0.25）中使用LC的一部分之后的单核细胞₅₀未恢复到对照组的水平。处理鱼的净化和恢复过程取决于浓度和恢复时间。