Retinitis pigmentosa (RP) encompasses a genetically diverse group of blinding inherited retinal diseases. In most subtypes the gene defect is expressed in the rod photoreceptors, yet in many affected individuals the cone photoreceptors undergo secondary degeneration, leading to loss of the remaining central vision. There is evidence that bioenergetic and oxidative stress are involved in this secondary cone loss. Photobiomodulation (PBM) uses low energy light in the far red or near-infrared spectrum to manipulate cellular activity. We have used a novel slit lamp-mounted retinal PBM laser to deliver precise energy levels to targeted retina. We showed that PBM laser attenuates oxidative and bioenergetic stress-induced photoreceptor loss in vitro and rescues cones in the rd1 murine model of RP. In a phase I trial (ACTRN12618000651280), foveal laser treatment was safe in humans with RP and temporarily recovered, on average, 5 letters of visual acuity.

中文翻译：

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激光和小鼠视网膜营养不良与激光光调节的锥体抢救。

色素性视网膜炎（RP）涵盖了遗传多样的致盲性遗传性视网膜疾病。在大多数亚型中，基因缺陷在视杆感光细胞中表达，但在许多受影响的个体中视锥感光细胞发生继发性变性，从而导致剩余的中央视力丧失。有证据表明，继发性视锥细胞丢失涉及生物能和氧化应激。光生物调节（PBM）使用远红外或近红外光谱中的低能量光来操纵细胞活动。我们已经使用了一种新型的安装在裂隙灯上的视网膜PBM激光来为目标视网膜提供精确的能量水平。我们显示，PBM激光可在体外减轻氧化和生物能应激诱导的感光细胞损失，并拯救RP1鼠模型中的视锥细胞。在第一阶段的试验（ACTRN12618000651280）中，