The main objective of this prospective cohort study was to evaluate whether traumatic microbleeds (TMBs) are a significant prognostic factor of return to work (RTW), post-traumatic symptoms, and overall recovery in patients with mild traumatic brain injury (mTBI). One hundred and thirteen patients with mTBI were recruited from the Helsinki University Hospital emergency units. All patients underwent multi-contrast 3T magnetic resonance imaging (MRI) 3–17 days after mTBI. Patients were evaluated in the Traumatic Brain Injury Outpatient Clinic of Helsinki University Hospital 1 month after injury. Post-concussion symptoms were assessed with the Post-Concussion Symptom Questionnaire (RPQ) and overall recovery was assessed with the Glasgow Outcome Scale Extended (GOS-E). Their time to RTW was continuously measured up to 1 year after TBI. Median RTW was 9 days (interquartile range [IQR] 4–30) after mTBI and full RTW rate after 1 year was 98%. Patients with TMBs (n = 22) did not have more post-concussion symptoms (median RPQ 10.0 vs. 7.0, p = 0.217) or worse overall recovery (58% vs. 56% with GOS-E = 8, p = 0.853) than patients without TMBs (n = 91). There was no significant difference in time to RTW (13.5 vs. 7.0 days, p = 0.063). In this study, patients with TMBs did not have delayed RTW or more post-concussion symptoms than other patients with mTBI. TMBs in mTBI do not seem to be a significant prognostic factor of RTW.

中文翻译：

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轻度创伤性脑损伤中的创伤性微出血与延迟返回工作或持续脑震荡后症状无关


这项前瞻性队列研究的主要目的是评估创伤性微出血 (TMB) 是否是轻度创伤性脑损伤 (mTBI) 患者重返工作岗位 (RTW)、创伤后症状和整体康复的重要预后因素。从赫尔辛基大学医院急诊室招募了 113 名 mTBI 患者。所有患者在 mTBI 后 3-17 天接受多重对比 3T 磁共振成像 (MRI)。受伤后1个月，患者在赫尔辛基大学医院脑外伤门诊接受评估。使用脑震荡后症状问卷（RPQ）评估脑震荡后症状，并使用格拉斯哥结果量表扩展（GOS-E）评估整体恢复情况。 TBI 后 1 年内持续测量他们的 RTW 时间。 mTBI 后中位 RTW 为 9 天（四分位距 [IQR] 4-30），1 年后完全 RTW 率为 98%。患有 TMB 的患者 ( n = 22) 并没有出现更多的脑震荡后症状（中位 RPQ 10.0 vs. 7.0， p = 0.217）或整体恢复较差（58% vs. 56%，GOS-E = 8， p = 0.853）与没有 TMB 的患者相比 ( n = 91)。 RTW 时间没有显着差异（13.5 天与 7.0 天， p = 0.063）。在这项研究中，与其他 mTBI 患者相比，TMB 患者没有延迟 RTW 或更多脑震荡后症状。 mTBI 中的 TMB 似乎不是 RTW 的重要预后因素。