Developments in synthetic chemistry are increasingly driven by improvements in the selectivity and sustainability of transformations. Bifunctional reagents, either as dual coupling partners or as a coupling partner in combination with an activating species, offer an atom-economic approach to chemical complexity, while suppressing the formation of waste. These reagents are employed in organic synthesis thanks to their ability to form complex organic architectures and empower novel reaction pathways. This Review describes several key bifunctional reagents by showcasing selected cornerstone research areas and examples, including radical reactions, C–H functionalization, cross-coupling, organocatalysis and cyclization reactions.

合成化学的发展越来越受到转化的选择性和可持续性的提高的推动。双功能试剂，无论是作为双偶联伙伴还是作为与活化物质结合的偶联伙伴，都为化学复杂性提供了一种原子经济的方法，同时抑制了废物的形成。由于这些试剂能够形成复杂的有机结构并赋予新的反应途径，因此被用于有机合成。本综述通过展示选定的基础研究领域和实例，描述了几种关键的双功能试剂，包括自由基反应、C-H 功能化、交叉偶联、有机催化和环化反应。