BACKGROUND:The contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) is a relative new algorithm for hepatocellular carcinoma (HCC) assessment. OBJECTIVE:To validate the diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for HCC. METHODS:Archivesof 873 patients with focal liver lesions (FLLs) undergoing CEUS were reviewed, and target images were read by two sonologists independently according to the CEUS LI-RADS. The diagnostic performance was calculated and compared. RESULTS:Assessment with reference to CEUS LI-RADS, 87 of 218 FLLs (39.9%) were categorized as LR-5, 131 of 218 FLLs (60.1%) were categorized as non-LR-5, 19 of 99 HCCs were categorized as non-LR-5, and 7 of 119 non-HCCs were categorized as LR-5. The sensitivity, specificity, AUROC, positive and negative predictive values of CEUS LI-RADS for diagnosing HCC were 80.81%(95%CI: 71.7%–88.0%), 94.1%(95%CI: 88.3%–97.6%), 0.87 (95%CI: 0.82–0.92), 91.9%(95%CI: 84.1%–96.7%), and 85.5%(95%CI: 78.3%–91.0%), respectively. CONCLUSIONS:The diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for the evaluation of HCCs is very good.

中文翻译：

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基于血管内灌注的对比增强超声 LI-RADS 在肝细胞癌评估中的诊断性能

背景：对比增强超声 (CEUS) 肝脏成像报告和数据系统 (LI-RADS) 是一种相对较新的肝细胞癌 (HCC) 评估算法。目的：验证基于血管内灌注的 CEUS LI-RADS 对 HCC 的诊断效率。方法：回顾了873例接受CEUS的肝脏局灶性病变（FLLs）患者的档案，由两名超声医师根据CEUS LI-RADS独立读取目标图像。计算和比较诊断性能。结果：参考 CEUS LI-RADS 进行评估，218 个 FLL 中的 87 个（39.9%）被归类为 LR-5，218 个 FLL 中的 131 个（60.1%）被归类为非 LR-5，99 个 HCC 中的 19 个被归类为非 LR-5，119 个非 HCC 中有 7 个被归类为 LR-5。敏感性、特异性、AUROC、CEUS LI-RADS 诊断 HCC 的阳性和阴性预测值为 80.81%(95%CI: 71.7%–88.0%), 94.1%(95%CI: 88.3%–97.6%), 0.87 (95%CI: 0.82–) 0.92)、91.9%(95%CI: 84.1%–96.7%) 和 85.5%(95%CI: 78.3%–91.0%)。结论:基于血管内灌注的CEUS LI-RADS评估HCC的诊断效率非常好。