Abstract

A new amide, named rehmagluamide (1), and a new hydroxycinnamic acid derivative, named nepetoidin F (2), together with six known compounds, 2′-O-methyluridine (3), puroglutamic acid (4), biliverdic acid (5), peterolactam (6), nicotinic acid (7), nicotinamide (8), were isolated from the fresh roots of Rehmannia glutinosa. All the structures of compounds were identified by the interpretation of their spectroscopic data and comparison with those reported in the literatures. The protective effects of compounds 1–7 on normal rat kidney tubule epithelioid (NRK-52e) cells injury induced by LPS were investigated. The results indicated that compounds 1, 2, and 7 exhibited protective effects against LPS-induced NRK 52e cells injury.

摘要

一种新的酰胺，名为 rehmagluamide ( 1 )，和一种新的羟基肉桂酸衍生物，名为 nepetoidin F ( 2 )，以及六种已知化合物，2'- O-甲基尿苷 ( 3 )、嘌呤谷氨酸 ( 4 )、胆绿酸 ( 5) )、彼得内酰胺( 6 )、烟酸( 7 )、烟酰胺( 8 )，均从生地黄的新鲜根中分离得到。通过对其光谱数据的解释和与文献报道的比较来确定化合物的所有结构。化合物1-7的保护作用研究了LPS对正常大鼠肾小管上皮样(NRK-52e)细胞的损伤。结果表明，化合物1，2，和7表现出对LPS诱导的NRK 52E细胞损伤具有保护作用。