Abstract

A new neolignan compound, tonkinensisin A (1), and two phenylpropanoid compounds, tonkinensisin B (2) and tonkinensisin C (3), were isolated from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw. The structures of these compounds were determined by spectroscopic analysis, and the relative configurations of compounds 1 and 3 were determined by J-based configuration analysis (JBCA) method. All compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by CCK-8 test in vitro.

中文翻译：

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得克苏木（Styrax tonkinensis）树脂中的新木脂素和苯丙烷类化合物

摘要

从Styrax tonkinensis（Pierre）Craib ex Hartw的树脂中分离出一种新的新木脂素化合物tonkinensisin A（1）和两种苯基丙烷化合物tonkinensisin B（2）和tonkinensisin C（3）。通过光谱分析确定这些化合物的结构，并通过基于J的构型分析（JBCA）方法确定化合物1和3的相对构型。通过体外CCK-8试验测定所有化合物对五种肿瘤细胞系（HepG-2，A549，Hela，MCF-7和PC-3）的细胞毒活性。