Abstract

Evaluation of the immunotropic effect of albendazole in low therapeutic doses has been carried out based on testing the ability of CBA × C57BL/6 mice lines to induce a delayed-type hypersensitivity (DTH) and the synthesis of antibodies against the thymus-dependent antigen. It has been shown that albendazole at doses of 2.5 and 5.0 mg/kg had no effect on the immune response of the cellular and humoral type. The DTH indices were 10.1 ± 3.14 and 10.8 ± 2.45%, respectively, and slightly exceeded those in the control by 3.1 and 10.2%. When albendazole was administered to immunized animals at doses of 2.5 and 5.0 mg/kg, log_1/2 of the blood hemagglutinin titer was 6.8 ± 0.46 and 7.0 ± 0.47, and effect indices of albendazole were 1.03 and 1.06. The titer of hemagglutinins in the blood of experimental animals exceeded that in the control by 3.0 and 6.1%, respectively. It has been shown that immunocompetent cells, which functionally provide the formation of delayed-type hypersensitivity and the synthesis of antibodies against the thymus-dependent antigen, are tolerant to albendazole. Albendazole at low therapeutic doses of 2.5 and 5.0 mg/kg with a single administration did not have immunotropic activity. At the tested doses, albendazole is not a regulator of cellular and humoral processes since it does not contribute to modulation of the functional activity of immunocompetent cells and their cooperative interaction, which are necessary for the development of an immune response of the cellular and humoral type.

中文翻译：

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低剂量阿苯达唑的免疫活性实验研究

摘要

基于测试CBA×C57BL / 6小鼠品系诱导迟发型超敏反应（DTH）的能力以及针对胸腺依赖性抗原的抗体合成，对低剂量的阿苯达唑的免疫效果进行了评估。已经显示2.5和5.0mg / kg的剂量的阿苯达唑对细胞和体液类型的免疫应答没有影响。DTH指数分别为10.1±3.14和10.8±2.45％，略高于对照组的3.1和10.2％。当将阿苯达唑以2.5和5.0 mg / kg的剂量施用于免疫动物时，log _1/2血液血凝素滴度的效价分别为6.8±0.46和7.0±0.47，阿苯达唑的疗效指数为1.03和1.06。实验动物血液中血凝素的效价分别比对照组高3.0％和6.1％。已经显示，功能上提供延迟型超敏反应的形成和针对胸腺依赖性抗原的抗体的合成的免疫活性细胞对阿苯达唑具有耐受性。单次给药的2.5和5.0 mg / kg低治疗剂量的阿苯达唑不具有免疫活性。在测试剂量下，阿苯达唑不是细胞和体液过程的调节剂，因为它不会调节免疫活性细胞的功能活性及其协同相互作用，