Many studies over the past decade have reported that internalized membrane receptors can trigger distinct signal activation, rather than being desensitized inside the cell. Here, we propose the concept of ‘internalized activation’ as a distinctive component of the receptor theory framework and exhibit its significance and role in diseases.

中文翻译：

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膜受体的内化激活：从现象到理论

过去十年中的许多研究报告称，内化膜受体可以触发不同的信号激活，而不是在细胞内脱敏。在这里，我们提出了“内化激活”的概念，作为受体理论框架的一个独特组成部分，并展示其在疾病中的重要性和作用。