This study offers a new wound dressing by immobilization of amino acid residues on partially carboxymethylated cotton nonwoven fabrics (CM-CN). To improve the absence of capacity to protect the open wound from infection, firstly, a usual cotton nonwoven fabric was chemically modified by utilizing a pad-dry-cure technique including a carboxymethylation procedure. Subsequently, the chicken feather wastes as a natural source were used for the cationization of CM-CN by the same method. Keratin successfully was extracted from chicken feathers using both chemical and enzymatic processes. Physicochemical and biological properties of the prepared samples were evaluated by FTIR, SEM, mechanical properties such as tensile, bending test and wrinkle recovery, biodegradation, permeability (air and water vapor), and MTT assay for cell viability and proliferation. The tensile strength increased to 200%, the air permeability almost doubled, and the greatest cell growth was observed for modified samples. According to the obtained results, enzymatic extraction was influential and the samples coated with enzyme-extracted keratin showed enhanced properties suitable for wound dressing applications.

这项研究通过将氨基酸残基固定在部分羧甲基化的棉质非织造布（CM-CN）上，提供了一种新的伤口敷料。为了改善缺乏保护开放伤口免受感染的能力，首先，通过使用包括羧甲基化步骤的垫式干固化技术对常用的棉非织造布进行化学改性。随后，将鸡羽毛废料作为天然来源通过相同方法用于CM-CN的阳离子化。使用化学和酶促工艺成功地从鸡毛中提取了角蛋白。通过FTIR，SEM，拉伸，弯曲试验和皱纹恢复等机械性能，生物降解性，渗透性（空气和水蒸气），和MTT测定细胞活力和增殖。拉伸强度提高到200％，透气率几乎翻倍，改性样品的细胞生长最大。根据获得的结果，酶提取具有影响力，并且用酶提取的角蛋白包被的样品显示出适合伤口敷料应用的增强的性能。