Pancreatitis is a common gastrointestinal disease with no effective therapeutic options, particularly for cases of severe acute and chronic pancreatitis (CP). Mesenchymal stromal cells (MSCs) are multipotent cells with diverse biological properties, including directional migration, paracrine, immunosuppressive, and antiinflammatory effects, which are considered an ideal candidate cell type for repairing tissue damage caused by various pathogenies. Several researchers have reported significant therapeutic efficacy of MSCs in animal models of acute and CP. However, the specific underlying mechanisms are yet to be clarified and clinical application of MSCs as pancreatitis therapy has rarely been reported. This review mainly focuses on the potential and challenges in clinical application of MSCs for treatment of acute and CP, along with discussion of the underlying molecular mechanisms.

中文翻译：

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胰腺炎间充质基质细胞治疗：进展与挑战

胰腺炎是一种常见的胃肠道疾病，没有有效的治疗选择，特别是对于严重的急性和慢性胰腺炎 (CP)。间充质基质细胞（MSCs）是具有多种生物学特性的多能细胞，包括定向迁移、旁分泌、免疫抑制和抗炎作用，被认为是修复各种病原体引起的组织损伤的理想候选细胞类型。几位研究人员报告了 MSCs 在急性和 CP 动物模型中的显着治疗效果。然而，具体的潜在机制仍有待阐明，并且很少报道MSCs作为胰腺炎治疗的临床应用。本综述主要关注 MSCs 在临床应用中治疗急性和 CP 的潜力和挑战，