Blighia sapida (B. sapida) K.D. Koenig (Family Sapindaceae) is a branchless straight bole approximately 15 m in length. The study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of B. sapida stem-bark using in vitro methods. Ethanol extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC), and quantitative phenolic and flavonoid contents. Anti-inflammatory activity was evaluated using albumin denaturation and membrane stabilization assays. The extract and its fractions exhibited radical scavenging and anti-inflammatory properties. The ethyl acetate fraction possessed maximum phenolic and flavonoid contents (136.67 ± 1.55 gallic acid equivalent mg/g and 75.76 ± 4.03 quercetin equivalent mg/g, respectively). Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC₅₀ = 0.09 ± 0.03 mg/mL DPPH, and values of 146.96 ± 3.81 ascorbic acid equivalent (AAE) mg/g and 359.20 ± 4.98 AAE mg/g for FRAP and TAC, respectively. Furthermore, the anti-inflammatory activity was revealed by inhibition of heat-induced albumin denaturation and red blood cell membrane stabilization at concentrations of 200–1000 μg/mL and 50–250 μg/mL, respectively. The ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities, with ethyl acetate fraction showing superior activity, which could be attributed to secondary metabolites, mainly phenolic compounds. Overall, the antioxidant and anti-inflammatory activities of B. sapida can be exploited by ethnomedicinal users.

Blighia sapida ( B. sapida ) KD Koenig (Family Sapindaceae) 是一种长约 15 m 的无枝直树干。该研究评估了乙醇提取物和B. sapida部分的抗氧化和抗炎活性使用体外方法的茎皮。研究了乙醇提取物及其馏分的 1,1-二苯基-2-苦基肼 (DPPH) 自由基清除活性、铁还原抗氧化能力 (FRAP)、总抗氧化能力 (TAC) 以及定量的酚类和类黄酮含量。使用白蛋白变性和膜稳定化测定评估抗炎活性。提取物及其部分表现出自由基清除和抗炎特性。乙酸乙酯部分具有最大的酚类和类黄酮含量（分别为 136.67 ± 1.55 没食子酸当量 mg/g 和 75.76 ± 4.03 槲皮素当量 mg/g）。抗氧化剂研究表明，乙酸乙酯部分表现出优异的活性，IC ₅₀ = 0.09 ± 0.03 mg/mL DPPH，FRAP 和 TAC 的值分别为 146.96 ± 3.81 抗坏血酸当量 (AAE) mg/g 和 359.20 ± 4.98 AAE mg/g。此外，分别在 200-1000 μg/mL 和 50-250 μg/mL 的浓度下，通过抑制热诱导的白蛋白变性和红细胞膜稳定来揭示抗炎活性。乙醇提取物和馏分表现出抗氧化和抗炎活性，乙酸乙酯馏分表现出优异的活性，这可能归因于次生代谢物，主要是酚类化合物。总体而言，民族药使用者可以利用B. sapida的抗氧化和抗炎活性。