Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long‐evans rats,Brain and Behavior

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Exposure to DMSO during infancy alters neurochemistry, social interactions, and brain morphology in long‐evans rats
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-04-10 , DOI: 10.1002/brb3.2146
Zachary Rabow _{1,

2} , Taryn Morningstar ₁ , Megan Showalter ₂ , Hailey Heil ₂ , Krista Thongphanh ₁ , Sili Fan ₂ , Joanne Chan ₁ , Verónica Martínez-Cerdeño _{1,

3,

4} , Robert Berman _{3,

5} , David Zagzag ₆ , Evgeny Nudler _{7,

8} , Oliver Fiehn ₂ , Mirna Lechpammer _{1,

3,

8,

9}

Affiliation

Dimethyl sulfoxide (DMSO) is a widely used solvent to dissolve hydrophobic substances for clinical uses and experimental in vivo purposes. While usually regarded safe, our prior studies suggest changes to behavior following DMSO exposure. We therefore evaluated the effects of a five‐day, short‐term exposure to DMSO on postnatal infant rats (P6‐10).

中文翻译：

婴儿期暴露于DMSO会改变长龄大鼠的神经化学，社交互动和大脑形态

二甲基亚砜（DMSO）是广泛用于溶解疏水性物质的溶剂，用于临床用途和体内实验目的。尽管通常认为是安全的，但我们的先前研究表明，暴露于DMSO后行为会发生变化。因此，我们评估了为期五天的短期DMSO暴露对产后幼鼠（P6-10）的影响。

更新日期：2021-05-14

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