Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects,Advanced Materials

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Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects
Advanced Materials ( IF 27.4 ) Pub Date : 2021-04-08 , DOI: 10.1002/adma.202005657
Hongyu Lin ₁ , Xiaoxue Tang ₁ , Ao Li ₁ , Jinhao Gao ₁

Affiliation

Visualization of biological targets such as crucial cells and biomolecules in living subjects is critical for the studies of important biological processes. Though ¹H magnetic resonance imaging (MRI) has demonstrated its power in offering detailed anatomical and pathological information, its capacity for in vivo tracking of biological targets is limited by the high biological background of ¹H. ¹⁹F distinguishes itself from its competitors as an exceptional complement to ¹H in MRI through its high sensitivity, low biological background, and broad chemical shift range. The specificity and sensitivity of ¹⁹F MRI can be further boosted with activatable nanoprobes. The advantages of ¹⁹F MRI with activatable nanoprobes enable in vivo detection and imaging at the cellular or even molecular level in deep tissues, rendering this technique appealing as a potential solution for visualization of biological targets in living subjects. Here, recent progress over the past decades on activatable ¹⁹F MRI nanoprobes made from three major ¹⁹F-containing compounds, as well as present challenges and potential opportunities, are summarized to provide a panoramic prospective for the people who are interested in this emerging and exciting field.

中文翻译：

可激活 19F MRI 纳米探针用于可视化活体生物靶标

生物靶标的可视化，例如活体中的关键细胞和生物分子，对于重要生物过程的研究至关重要。尽管¹ H 磁共振成像 (MRI) 已证明其在提供详细的解剖和病理信息方面的能力，但其对生物目标的体内跟踪能力受到¹ H的高生物背景的限制。 ¹⁹ F 将自己与竞争对手区分开来，作为通过其高灵敏度、低生物背景和广泛的化学位移范围，对 MRI中的¹ H 进行了出色的补充。可激活纳米探针可进一步提高¹⁹ F MRI的特异性和敏感性。¹⁹的优势具有可激活纳米探针的 F MRI 能够在深部组织的细胞甚至分子水平上进行体内检测和成像，从而使该技术成为可视化活体生物靶标的潜在解决方案。在这里，总结了过去几十年来由三种主要含¹⁹ F 化合物制成的可激活¹⁹ F MRI 纳米探针的最新进展，以及当前的挑战和潜在机遇，为对这一新兴和令人兴奋的领域。

更新日期：2021-04-08

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