Currently, the reported endoscopic system cannot meet the necessary conditions for real-time and optical-resolution clinical application simultaneously. In this study, by utilizing a high-repetition-rate laser and optimizing the overall structure of the probe, a real-time optical-resolution photoacoustic endoscope was developed, which could image targets in real time while maintaining a relatively constant lateral resolution. The endoscopic system has a best-resolution of 19μm and a real-time imaging speed of 25Hz. Experimental results demonstrate that this approach will push the promotion and commercialization of photoacoustic endoscopic imaging in a variety of preclinical and clinical applications.

目前，报道的内窥镜系统不能同时满足实时和光学分辨率临床应用的必要条件。本研究利用高重复率激光器，优化探头整体结构，研制出一种实时光学分辨率光声内窥镜，可在保持相对恒定的横向分辨率的同时对目标进行实时成像。的内窥镜系统具有最佳分辨率的19 μ m和25Hz的的实时成像速度。实验结果表明，这种方法将推动光声内窥镜成像在各种临床前和临床应用中的推广和商业化。