Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions. A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05. Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

中文翻译：

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载脂蛋白基因多态性与高脂血症之间的关联：一项荟萃分析

高脂血症在心脑血管疾病的病因中起着重要作用。近年来，许多研究探索了载脂蛋白基因多态性对高脂血症的影响，但是在与来自不同地区的不同人群的关联中发现了相当大的差异和不确定性。总共包括59篇文章，在病例组中总共包含13,843名高脂血症患者，在对照组中包含15,398名健康对照者。数据的荟萃分析表明，APOA5-1131 T> C，APOA1-75 bp，APOB XbaI和APOE基因多态性与高脂血症显着相关，OR值分别为1.996、1.228、1.444和1.710。所有P值均小于0.05。数据的荟萃分析表明，APOA5 1131 T的C等位基因> C，